| GURÍN, Dominik, Marek SLÁVIK, Markéta HERMANOVÁ, Iveta SELINGEROVÁ, Tomáš KAZDA, Michal HENDRYCH, Tetiana SHATOKHINA a Marcela VESELÁ. The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE. HOBOKEN: WILEY, 2020, roč. 49, č. 9, s. 886-896. ISSN 0904-2512. Dostupné z: https://dx.doi.org/10.1111/jop.13055. |
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@article{1673160,
author = {Gurín, Dominik and Slávik, Marek and Hermanová, Markéta and Selingerová, Iveta and Kazda, Tomáš and Hendrych, Michal and Shatokhina, Tetiana and Veselá, Marcela},
article_location = {HOBOKEN},
article_number = {9},
doi = {http://dx.doi.org/10.1111/jop.13055},
keywords = {CD8; HPV; oropharyngeal squamous cell carcinoma; PD-L1; tumor-infiltrating lymphocytes},
language = {eng},
issn = {0904-2512},
journal = {JOURNAL OF ORAL PATHOLOGY & MEDICINE},
title = {The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma},
url = {https://onlinelibrary.wiley.com/doi/full/10.1111/jop.13055},
volume = {49},
year = {2020}
}
TY - JOUR
ID - 1673160
AU - Gurín, Dominik - Slávik, Marek - Hermanová, Markéta - Selingerová, Iveta - Kazda, Tomáš - Hendrych, Michal - Shatokhina, Tetiana - Veselá, Marcela
PY - 2020
TI - The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma
JF - JOURNAL OF ORAL PATHOLOGY & MEDICINE
VL - 49
IS - 9
SP - 886-896
EP - 886-896
PB - WILEY
SN - 09042512
KW - CD8
KW - HPV
KW - oropharyngeal squamous cell carcinoma
KW - PD-L1
KW - tumor-infiltrating lymphocytes
UR - https://onlinelibrary.wiley.com/doi/full/10.1111/jop.13055
L2 - https://onlinelibrary.wiley.com/doi/full/10.1111/jop.13055
N2 - Background We examined PD-L1 expression on tumor cells (TCs) and immune cells (ICs) and density of CD3(+)and CD8(+)tumor-infiltrating lymphocytes (TILs) in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigated their significance on clinicopathological characteristics and clinical outcomes. Methods In a cohort of 65 patients treated by definitive intensity-modulated radiotherapy (IMRT) with curative intent, immunohistochemical analysis of PD-L1 expression on TCs and ICs, and TIL subtyping was performed on primary biopsy tumor tissues, followed by prognostic evaluation of these immune response-related parameters including classification into four tumor immune microenvironment (TIM) types. To evaluate HPV status, p16 immunohistochemistry was performed. Results Densities of CD3(+)and CD8(+)TILs and PD-L1 expressions on TCs and ICs were significantly higher in p16+/HPV-mediated OPSCC. Patients with high densities of stromal CD8(+)TILs displayed significantly better overall survival (OS) and progression-free survival (PFS). PD-L1 expression neither on tumor cells nor on immune cells affected survival outcomes. Distribution of TIM types based on the combination of PD-L1 expression on TCs and densities of CD8(+)TILs is significantly different in p16+ compared with p16- OPSCC. In type III TIM (TC-PD-L1+/low CD8(+)TIL density), significantly better OS was shown in p16+ group compared with p16- OPSCC. Conclusion The prognostic and predictive role of tumor immune microenvironment was confirmed for patients with OPSCC. Combining HPV status with the evaluation of densities of CD8(+)TILs and PD-L1 expression including TIM classification might be of high clinical interest and warrants further prospective evaluation.
ER -
GURÍN, Dominik, Marek SLÁVIK, Markéta HERMANOVÁ, Iveta SELINGEROVÁ, Tomáš KAZDA, Michal HENDRYCH, Tetiana SHATOKHINA a Marcela VESELÁ. The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma. \textit{JOURNAL OF ORAL PATHOLOGY \&{} MEDICINE}. HOBOKEN: WILEY, 2020, roč.~49, č.~9, s.~886-896. ISSN~0904-2512. Dostupné z: https://dx.doi.org/10.1111/jop.13055.
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