KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA, Jan KUBOVY, Martina HLOSTOVA a Michal UHER. Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. ABINGDON: TAYLOR & FRANCIS LTD, 2020, roč. 55, č. 6, s. 671-676. ISSN 0036-5521. Dostupné z: https://dx.doi.org/10.1080/00365521.2020.1774921. |
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@article{1673167, author = {Kojecký, Vladimír and Matous, Jan and Kianička, Bohuslav and Dite, Petr and Zadorova, Zdena and Kubovy, Jan and Hlostova, Martina and Uher, Michal}, article_location = {ABINGDON}, article_number = {6}, doi = {http://dx.doi.org/10.1080/00365521.2020.1774921}, keywords = {Inflammatory bowel disease; vitamin D deficiency; vitamin D intake; dietary supplements; body weight}, language = {eng}, issn = {0036-5521}, journal = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}, title = {Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation}, url = {https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921}, volume = {55}, year = {2020} }
TY - JOUR ID - 1673167 AU - Kojecký, Vladimír - Matous, Jan - Kianička, Bohuslav - Dite, Petr - Zadorova, Zdena - Kubovy, Jan - Hlostova, Martina - Uher, Michal PY - 2020 TI - Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation JF - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY VL - 55 IS - 6 SP - 671-676 EP - 671-676 PB - TAYLOR & FRANCIS LTD SN - 00365521 KW - Inflammatory bowel disease KW - vitamin D deficiency KW - vitamin D intake KW - dietary supplements KW - body weight UR - https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921 L2 - https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921 N2 - Objectives:Body weight is one of the factors affecting blood levels of 25-hydroxyvitamin D (25OHD). The aim of this study was to establish whether a vitamin D (vitD) weight-based dosing is more appropriate to a fixed daily dose in patients with inflammatory bowel disease (IBD). Materials/methods:This was an open label randomised trial. Patients with IBD were assigned to receive oral cholecalciferol at a dose of 28 IU/kg (IU/kg) or 2000 IU per day (IU/day) for 12 weeks during winter months. 25OHD plasma levels and other biochemical parameters were measured at baseline and after supplementation period. The primary outcome measure was 25OHD level after a follow-up period. Results:A total of 173 patients were analysed. The mean BMI was 25.5 +/- 5.1 and initial mean 25OHD level was 62.7 +/- 25.5 nmol/l. A similar increase (9.7 +/- 26.9 vs 9.8 +/- 26.7 nmol/l) in 25OHD levels occurred both in IU/kg and IU/day group. The proportion of subjects with normal and sub-normal levels following the substitution was comparable irrespective of body weight. The change in 25OHD level correlated positively only with the dose of vitD (p < .001) and negatively with the baseline 25OHD level (p < .001). A sustained 25OHD level of 75 nmol/l corresponds with a calculated daily vitD dose of 2034 IU. Conclusions:Weight-based dosing of vitamin D is not superior to a fixed dose in order to maintain stable 25OHD levels in IBD patients. Cholecalciferol dose of 2,000 IU/day is safe and sufficient during winter period. ER -
KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA, Jan KUBOVY, Martina HLOSTOVA a Michal UHER. Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation. \textit{SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}. ABINGDON: TAYLOR \&{} FRANCIS LTD, 2020, roč.~55, č.~6, s.~671-676. ISSN~0036-5521. Dostupné z: https://dx.doi.org/10.1080/00365521.2020.1774921.
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