| KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA, Jan KUBOVY, Martina HLOSTOVA and Michal UHER. Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. ABINGDON: TAYLOR & FRANCIS LTD, 2020, vol. 55, No 6, p. 671-676. ISSN 0036-5521. Available from: https://dx.doi.org/10.1080/00365521.2020.1774921. |
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@article{1673167,
author = {Kojecký, Vladimír and Matous, Jan and Kianička, Bohuslav and Dite, Petr and Zadorova, Zdena and Kubovy, Jan and Hlostova, Martina and Uher, Michal},
article_location = {ABINGDON},
article_number = {6},
doi = {http://dx.doi.org/10.1080/00365521.2020.1774921},
keywords = {Inflammatory bowel disease; vitamin D deficiency; vitamin D intake; dietary supplements; body weight},
language = {eng},
issn = {0036-5521},
journal = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY},
title = {Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation},
url = {https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921},
volume = {55},
year = {2020}
}
TY - JOUR
ID - 1673167
AU - Kojecký, Vladimír - Matous, Jan - Kianička, Bohuslav - Dite, Petr - Zadorova, Zdena - Kubovy, Jan - Hlostova, Martina - Uher, Michal
PY - 2020
TI - Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation
JF - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
VL - 55
IS - 6
SP - 671-676
EP - 671-676
PB - TAYLOR & FRANCIS LTD
SN - 00365521
KW - Inflammatory bowel disease
KW - vitamin D deficiency
KW - vitamin D intake
KW - dietary supplements
KW - body weight
UR - https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921
L2 - https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921
N2 - Objectives:Body weight is one of the factors affecting blood levels of 25-hydroxyvitamin D (25OHD). The aim of this study was to establish whether a vitamin D (vitD) weight-based dosing is more appropriate to a fixed daily dose in patients with inflammatory bowel disease (IBD). Materials/methods:This was an open label randomised trial. Patients with IBD were assigned to receive oral cholecalciferol at a dose of 28 IU/kg (IU/kg) or 2000 IU per day (IU/day) for 12 weeks during winter months. 25OHD plasma levels and other biochemical parameters were measured at baseline and after supplementation period. The primary outcome measure was 25OHD level after a follow-up period. Results:A total of 173 patients were analysed. The mean BMI was 25.5 +/- 5.1 and initial mean 25OHD level was 62.7 +/- 25.5 nmol/l. A similar increase (9.7 +/- 26.9 vs 9.8 +/- 26.7 nmol/l) in 25OHD levels occurred both in IU/kg and IU/day group. The proportion of subjects with normal and sub-normal levels following the substitution was comparable irrespective of body weight. The change in 25OHD level correlated positively only with the dose of vitD (p < .001) and negatively with the baseline 25OHD level (p < .001). A sustained 25OHD level of 75 nmol/l corresponds with a calculated daily vitD dose of 2034 IU. Conclusions:Weight-based dosing of vitamin D is not superior to a fixed dose in order to maintain stable 25OHD levels in IBD patients. Cholecalciferol dose of 2,000 IU/day is safe and sufficient during winter period.
ER -
KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA, Jan KUBOVY, Martina HLOSTOVA and Michal UHER. Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation. \textit{SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}. ABINGDON: TAYLOR \&{} FRANCIS LTD, 2020, vol.~55, No~6, p.~671-676. ISSN~0036-5521. Available from: https://dx.doi.org/10.1080/00365521.2020.1774921.
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