Heart rate as an independent predictor of long term mortality
of acute heart failure patients in sinus rhythm according to
their ejection fraction: data from the AHEAD registry

J 2020

Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry

JARKOVSKÝ, Jiří, Jindřich ŠPINAR, Benoit TYL, Francoise FOUGEROUSSE, Jiří VÍTOVEC et. al.

Basic information

Original name

Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry

Authors

JARKOVSKÝ, Jiří (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Benoit TYL (250 France), Francoise FOUGEROUSSE (250 France), Jiří VÍTOVEC (203 Czech Republic, belonging to the institution), Ales LINHART (203 Czech Republic), Petr WIDIMSKY (203 Czech Republic), Roman MIKLÍK (203 Czech Republic), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Jan BELOHLAVEK (203 Czech Republic), Filip MALEK (203 Czech Republic), Marián FELŠŐCI (703 Slovakia, belonging to the institution), Jiri KETTNER (203 Czech Republic), Petr OSTADAL (203 Czech Republic), Jan VACLAVIK (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic, belonging to the institution), Alexandre MEBAZAA (250 France), Alain Cohen SOLAL (250 France) and Jiří PAŘENICA (203 Czech Republic, belonging to the institution)

Edition

European Journal of Internal Medicine, AMSTERDAM, ELSEVIER, 2020, 0953-6205

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.487

RIV identification code

RIV/00216224:14110/20:00116142

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ejim.2020.04.022

UT WoS

000553841300018

Keywords in English

Acute heart failure; AHEAD; Prognosis; Sinus rhythm; Heart rate; Preserved ejection fraction

Abstract

V originále

Background: Heart rate (HR) at admission in patients with acute heart failure (AHF) has been shown to be an important risk marker of in-hospital mortality. However, its relation with mid and long-term prognosis as well as the impact of Ejection Fraction (EF) is unknown. Our objective was to study the relationship between long-term survival and HR at admission depending on EF in a cohort of patients hospitalized for AHF. Methods: We analyzed the data of 2335 patients in sinus rhythm hospitalized for AHF from AHEAD registry. Patients with cardiogenic shock and AHF from surgical or non-cardiac etiology were excluded. Results: Survival rates at 6 and 12 months were 84.8% and 78% respectively. Increased age, decreased diastolic BP, lack of PCI during hospitalization, increased creatinine level and increased HR (with different cut-offs according to EF categories) were found as predictors whatever the EF at 6 and 12 months. Optimal prognostic cut-offs of heart rate were identified for Heart Failure with reduced EF at 100 bpm, for Heart Failure with mid-range EF at 90 bpm and for Heart Failure with preserved EF at 80 bpm for both 6 and 12 months. Conclusion: Our study suggests that HR at admission appears to be an independent prognostic parameter in AHF patients in sinus rhythm irrespective of EF and can be used to classify patients according to the severity of the disease.

Citovat

JARKOVSKÝ, Jiří, Jindřich ŠPINAR, Benoit TYL, Francoise FOUGEROUSSE, Jiří VÍTOVEC, Ales LINHART, Petr WIDIMSKY, Roman MIKLÍK, Lenka ŠPINAROVÁ, Jan BELOHLAVEK, Filip MALEK, Marián FELŠŐCI, Jiri KETTNER, Petr OSTADAL, Jan VACLAVIK, Ladislav DUŠEK, Petr LOKAJ, Alexandre MEBAZAA, Alain Cohen SOLAL and Jiří PAŘENICA. Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry. European Journal of Internal Medicine. AMSTERDAM: ELSEVIER, 2020, vol. 78, AUG 2020, p. 88-94. ISSN 0953-6205. Available from: https://dx.doi.org/10.1016/j.ejim.2020.04.022.

@article{1673238,
   author = {Jarkovský, Jiří and Špinar, Jindřich and Tyl, Benoit and Fougerousse, Francoise and Vítovec, Jiří and Linhart, Ales and Widimsky, Petr and Miklík, Roman and Špinarová, Lenka and Belohlavek, Jan and Malek, Filip and Felšőci, Marián and Kettner, Jiri and Ostadal, Petr and Vaclavik, Jan and Dušek, Ladislav and Lokaj, Petr and Mebazaa, Alexandre and Solal, Alain Cohen and Pařenica, Jiří},
   article_location = {AMSTERDAM},
   article_number = {AUG 2020},
   doi = {http://dx.doi.org/10.1016/j.ejim.2020.04.022},
   keywords = {Acute heart failure; AHEAD; Prognosis; Sinus rhythm; Heart rate; Preserved ejection fraction},
   language = {eng},
   issn = {0953-6205},
   journal = {European Journal of Internal Medicine},
   title = {Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry},
   url = {https://www.sciencedirect.com/science/article/pii/S0953620520301369?via%3Dihub},
   volume = {78},
   year = {2020}
}

TY  - JOUR
ID  - 1673238
AU  - Jarkovský, Jiří - Špinar, Jindřich - Tyl, Benoit - Fougerousse, Francoise - Vítovec, Jiří - Linhart, Ales - Widimsky, Petr - Miklík, Roman - Špinarová, Lenka - Belohlavek, Jan - Malek, Filip - Felšőci, Marián - Kettner, Jiri - Ostadal, Petr - Vaclavik, Jan - Dušek, Ladislav - Lokaj, Petr - Mebazaa, Alexandre - Solal, Alain Cohen - Pařenica, Jiří
PY  - 2020
TI  - Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry
JF  - European Journal of Internal Medicine
VL  - 78
IS  - AUG 2020
SP  - 88-94
EP  - 88-94
PB  - ELSEVIER
SN  - 09536205
KW  - Acute heart failure
KW  - AHEAD
KW  - Prognosis
KW  - Sinus rhythm
KW  - Heart rate
KW  - Preserved ejection fraction
UR  - https://www.sciencedirect.com/science/article/pii/S0953620520301369?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0953620520301369?via%3Dihub
N2  - Background: Heart rate (HR) at admission in patients with acute heart failure (AHF) has been shown to be an important risk marker of in-hospital mortality. However, its relation with mid and long-term prognosis as well as the impact of Ejection Fraction (EF) is unknown. Our objective was to study the relationship between long-term survival and HR at admission depending on EF in a cohort of patients hospitalized for AHF. Methods: We analyzed the data of 2335 patients in sinus rhythm hospitalized for AHF from AHEAD registry. Patients with cardiogenic shock and AHF from surgical or non-cardiac etiology were excluded. Results: Survival rates at 6 and 12 months were 84.8% and 78% respectively. Increased age, decreased diastolic BP, lack of PCI during hospitalization, increased creatinine level and increased HR (with different cut-offs according to EF categories) were found as predictors whatever the EF at 6 and 12 months. Optimal prognostic cut-offs of heart rate were identified for Heart Failure with reduced EF at 100 bpm, for Heart Failure with mid-range EF at 90 bpm and for Heart Failure with preserved EF at 80 bpm for both 6 and 12 months. Conclusion: Our study suggests that HR at admission appears to be an independent prognostic parameter in AHF patients in sinus rhythm irrespective of EF and can be used to classify patients according to the severity of the disease.
ER  -

JARKOVSKÝ, Jiří, Jindřich ŠPINAR, Benoit TYL, Francoise FOUGEROUSSE, Jiří VÍTOVEC, Ales LINHART, Petr WIDIMSKY, Roman MIKLÍK, Lenka ŠPINAROVÁ, Jan BELOHLAVEK, Filip MALEK, Marián FELŠ$\backslash$H OCI, Jiri KETTNER, Petr OSTADAL, Jan VACLAVIK, Ladislav DUŠEK, Petr LOKAJ, Alexandre MEBAZAA, Alain Cohen SOLAL and Jiří PAŘENICA. Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry. \textit{European Journal of Internal Medicine}. AMSTERDAM: ELSEVIER, 2020, vol.~78, AUG 2020, p.~88-94. ISSN~0953-6205. Available from: https://dx.doi.org/10.1016/j.ejim.2020.04.022.

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