Hospitals and Pharmacies as Sources of Contamination by
Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech
Republic

C 2020

Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic

BLÁHOVÁ, Lucie, Lenka DOLEŽALOVÁ, Jan KUTA, Šárka KOZÁKOVÁ, Luděk BLÁHA et. al.

Basic information

Original name

Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic

Authors

BLÁHOVÁ, Lucie (203 Czech Republic, belonging to the institution), Lenka DOLEŽALOVÁ (203 Czech Republic), Jan KUTA (203 Czech Republic, belonging to the institution), Šárka KOZÁKOVÁ (203 Czech Republic) and Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cham, Fate and Effects of Anticancer Drugs in the Environment, p. 57-70, 14 pp. 2020

Publisher

Springer

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

10500 1.5. Earth and related environmental sciences

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

electronic version available online

References:

URL

RIV identification code

RIV/00216224:14310/20:00116151

Organization unit

Faculty of Science

ISBN

978-3-030-21047-2

DOI

http://dx.doi.org/10.1007/978-3-030-21048-9_3

UT WoS

000716576600004

Keywords in English

Occupational exposure; Surface contamination; 5-Fluorouracil; Cyclophosphamide; Platinum drugs; LC-MS/MS; ICP MS

Abstract

V originále

Two of the important contamination sources by antineoplastic drugs (AD) are hospitals and pharmacies. Unwanted releases have been documented during all steps of the preparation and administration of these hazardous drugs to patients leading to contamination of both working places and outside environment (transfer by aerosols, contaminated materials, or water after cleaning). Here we present results of a long-term project from 21 hospitals in the Czech Republic (971 samples; 2008–2016) investigating the contamination by major AD-5-fluorouracil (FU), cyclophosphamide (CP) and platinum drugs (total Pt as a sum of broadly used Pt-based drugs cisplatin, oxaliplatin, and carboplatin). In general, lower median levels of contamination have been found in pharmacies, which could be attributed to personnel education and higher safety working standards. On the other hand, surface contamination in other hospital areas exceeded the suggested threshold guidance values (TGVs) in up to 40% of samples depending on the monitored drug (TGVs being 67, 12, and 38 pg per square cm for CP, Pt, and FU, respectively). The highest values, maxima exceeding 29,000 and 49,000 pg per square cm for CP and FU, respectively, have repeatedly been found in outpatient clinics. The monitoring and discussions with responsible managers promoted the implementation of proper procedures and technologies that resulted in an overall decrease of the contamination during the monitored period.

Links

EF16_013/0001761, research and development project

Name: RECETOX RI

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

NV18-09-00188, research and development project

Name: Monitoring expozice cytotoxickým léčivům u pracovníků ve zdravotnictví a rodinných příslušníků onkologických pacientů, analýza rizik, zpracování doporučených postupů

Investor: Ministry of Health of the CR

Citovat

BLÁHOVÁ, Lucie, Lenka DOLEŽALOVÁ, Jan KUTA, Šárka KOZÁKOVÁ and Luděk BLÁHA. Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic. Online. In Ester Heath, Marina Isidori, Tina Kosjek, Metka Filipič. Fate and Effects of Anticancer Drugs in the Environment. Cham: Springer, 2020, p. 57-70. ISBN 978-3-030-21047-2. Available from: https://dx.doi.org/10.1007/978-3-030-21048-9_3.

@inbook{1673436,
   author = {Bláhová, Lucie and Doležalová, Lenka and Kuta, Jan and Kozáková, Šárka and Bláha, Luděk},
   address = {Cham},
   booktitle = {Fate and Effects of Anticancer Drugs in the Environment},
   doi = {http://dx.doi.org/10.1007/978-3-030-21048-9_3},
   editor = {Ester Heath, Marina Isidori, Tina Kosjek, Metka Filipič},
   keywords = {Occupational exposure; Surface contamination; 5-Fluorouracil; Cyclophosphamide; Platinum drugs; LC-MS/MS; ICP MS},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Cham},
   isbn = {978-3-030-21047-2},
   pages = {57-70},
   publisher = {Springer},
   title = {Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic},
   url = {https://link.springer.com/chapter/10.1007%2F978-3-030-21048-9_3},
   year = {2020}
}

TY  - CHAP
ID  - 1673436
AU  - Bláhová, Lucie - Doležalová, Lenka - Kuta, Jan - Kozáková, Šárka - Bláha, Luděk
PY  - 2020
TI  - Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic
VL  - Neuveden
PB  - Springer
CY  - Cham
SN  - 9783030210472
KW  - Occupational exposure
KW  - Surface contamination
KW  - 5-Fluorouracil
KW  - Cyclophosphamide
KW  - Platinum drugs
KW  - LC-MS/MS
KW  - ICP MS
UR  - https://link.springer.com/chapter/10.1007%2F978-3-030-21048-9_3
L2  - https://link.springer.com/chapter/10.1007%2F978-3-030-21048-9_3
N2  - Two of the important contamination sources by antineoplastic drugs (AD) are hospitals and pharmacies. Unwanted releases have been documented during all steps of the preparation and administration of these hazardous drugs to patients leading to contamination of both working places and outside environment (transfer by aerosols, contaminated materials, or water after cleaning). Here we present results of a long-term project from 21 hospitals in the Czech Republic (971 samples; 2008–2016) investigating the contamination by major AD-5-fluorouracil (FU), cyclophosphamide (CP) and platinum drugs (total Pt as a sum of broadly used Pt-based drugs cisplatin, oxaliplatin, and carboplatin). In general, lower median levels of contamination have been found in pharmacies, which could be attributed to personnel education and higher safety working standards. On the other hand, surface contamination in other hospital areas exceeded the suggested threshold guidance values (TGVs) in up to 40% of samples depending on the monitored drug (TGVs being 67, 12, and 38 pg per square cm for CP, Pt, and FU, respectively). The highest values, maxima exceeding 29,000 and 49,000 pg per square cm for CP and FU, respectively, have repeatedly been found in outpatient clinics. The monitoring and discussions with responsible managers promoted the implementation of proper procedures and technologies that resulted in an overall decrease of the contamination during the monitored period.
ER  -

BLÁHOVÁ, Lucie, Lenka DOLEŽALOVÁ, Jan KUTA, Šárka KOZÁKOVÁ and Luděk BLÁHA. Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic. Online. In Ester Heath, Marina Isidori, Tina Kosjek, Metka Filipič. \textit{Fate and Effects of Anticancer Drugs in the Environment}. Cham: Springer, 2020, p.~57-70. ISBN~978-3-030-21047-2. Available from: https://dx.doi.org/10.1007/978-3-030-21048-9\_{}3.

Detailed Information on Publication Record