The therapeutic effect of B-type natriuretic peptides in acute
decompensated heart failure

J 2020

The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure

CAPRNDA, Martin, Anthony ZULLI, Haaris A. SHIWANI, Peter KUBATKA, Slavomira FILIPOVA et. al.

Basic information

Original name

The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure

Authors

CAPRNDA, Martin (703 Slovakia), Anthony ZULLI (36 Australia), Haaris A. SHIWANI (826 United Kingdom of Great Britain and Northern Ireland), Peter KUBATKA (703 Slovakia), Slavomira FILIPOVA (703 Slovakia), Vanda VALENTOVA (703 Slovakia), Katarina GAZDIKOVA (703 Slovakia), Ioana MOZOS (642 Romania), Andrius BERUKSTIS (440 Lithuania), Aleksandras LAUCEVICIUS (440 Lithuania), Ivan ŘIHÁČEK (203 Czech Republic, belonging to the institution), Jozef DRAGASEK (703 Slovakia), Robert PROSECKY (203 Czech Republic), Emmanuel E. EGOM (124 Canada), Robert STAFFA (203 Czech Republic, belonging to the institution), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and Vladimir KRASNIK (703 Slovakia)

Edition

Clinical and Experimental Pharmacology and Physiology, Australia, Blackwell Publishing Australia, 2020, 0305-1870

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.557

RIV identification code

RIV/00216224:14110/20:00116163

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/1440-1681.13290

UT WoS

000520715900001

Keywords in English

B-type natriuretic peptide; clinical effectiveness; heart failure; pharmacotherapy

Abstract

V originále

B-type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.

Citovat

CAPRNDA, Martin, Anthony ZULLI, Haaris A. SHIWANI, Peter KUBATKA, Slavomira FILIPOVA, Vanda VALENTOVA, Katarina GAZDIKOVA, Ioana MOZOS, Andrius BERUKSTIS, Aleksandras LAUCEVICIUS, Ivan ŘIHÁČEK, Jozef DRAGASEK, Robert PROSECKY, Emmanuel E. EGOM, Robert STAFFA, Peter KRUŽLIAK and Vladimir KRASNIK. The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure. Clinical and Experimental Pharmacology and Physiology. Australia: Blackwell Publishing Australia, 2020, vol. 47, No 7, p. 1120-1133. ISSN 0305-1870. Available from: https://dx.doi.org/10.1111/1440-1681.13290.

@article{1673737,
   author = {Caprnda, Martin and Zulli, Anthony and Shiwani, Haaris A. and Kubatka, Peter and Filipova, Slavomira and Valentova, Vanda and Gazdikova, Katarina and Mozos, Ioana and Berukstis, Andrius and Laucevicius, Aleksandras and Řiháček, Ivan and Dragasek, Jozef and Prosecky, Robert and Egom, Emmanuel E. and Staffa, Robert and Kružliak, Peter and Krasnik, Vladimir},
   article_location = {Australia},
   article_number = {7},
   doi = {http://dx.doi.org/10.1111/1440-1681.13290},
   keywords = {B-type natriuretic peptide; clinical effectiveness; heart failure; pharmacotherapy},
   language = {eng},
   issn = {0305-1870},
   journal = {Clinical and Experimental Pharmacology and Physiology},
   title = {The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290},
   volume = {47},
   year = {2020}
}

TY  - JOUR
ID  - 1673737
AU  - Caprnda, Martin - Zulli, Anthony - Shiwani, Haaris A. - Kubatka, Peter - Filipova, Slavomira - Valentova, Vanda - Gazdikova, Katarina - Mozos, Ioana - Berukstis, Andrius - Laucevicius, Aleksandras - Řiháček, Ivan - Dragasek, Jozef - Prosecky, Robert - Egom, Emmanuel E. - Staffa, Robert - Kružliak, Peter - Krasnik, Vladimir
PY  - 2020
TI  - The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure
JF  - Clinical and Experimental Pharmacology and Physiology
VL  - 47
IS  - 7
SP  - 1120-1133
EP  - 1120-1133
PB  - Blackwell Publishing Australia
SN  - 03051870
KW  - B-type natriuretic peptide
KW  - clinical effectiveness
KW  - heart failure
KW  - pharmacotherapy
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290
N2  - B-type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.
ER  -

CAPRNDA, Martin, Anthony ZULLI, Haaris A. SHIWANI, Peter KUBATKA, Slavomira FILIPOVA, Vanda VALENTOVA, Katarina GAZDIKOVA, Ioana MOZOS, Andrius BERUKSTIS, Aleksandras LAUCEVICIUS, Ivan ŘIHÁČEK, Jozef DRAGASEK, Robert PROSECKY, Emmanuel E. EGOM, Robert STAFFA, Peter KRUŽLIAK and Vladimir KRASNIK. The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure. \textit{Clinical and Experimental Pharmacology and Physiology}. Australia: Blackwell Publishing Australia, 2020, vol.~47, No~7, p.~1120-1133. ISSN~0305-1870. Available from: https://dx.doi.org/10.1111/1440-1681.13290.

Detailed Information on Publication Record