Primary Mammary Organoid Model of Lactation and Involution

@article{1673739,
   author = {Sumbal, Jakub and Chiche, Aurelie and Charifou, Elsa and Koledová, Zuzana and Li, Han},
   article_location = {Lausanne},
   article_number = {MAR 2020},
   doi = {http://dx.doi.org/10.3389/fcell.2020.00068},
   keywords = {3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {Primary Mammary Organoid Model of Lactation and Involution},
   url = {https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full},
   volume = {8},
   year = {2020}
}

TY  - JOUR
ID  - 1673739
AU  - Sumbal, Jakub - Chiche, Aurelie - Charifou, Elsa - Koledová, Zuzana - Li, Han
PY  - 2020
TI  - Primary Mammary Organoid Model of Lactation and Involution
JF  - Frontiers in Cell and Developmental Biology
VL  - 8
IS  - MAR 2020
SP  - 1-13
EP  - 1-13
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - 3D culture
KW  - fibroblast growth factor 2
KW  - involution
KW  - lactation
KW  - mammary gland
KW  - milk production
KW  - organoid
KW  - prolactin
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
L2  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
N2  - Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
ER  - 

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ and Han LI. Primary Mammary Organoid Model of Lactation and Involution. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2020, vol.~8, MAR 2020, p.~1-13. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2020.00068.