Primary Mammary Organoid Model of Lactation and Involution

J 2020

Primary Mammary Organoid Model of Lactation and Involution

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ, Han LI et. al.

Basic information

Original name

Primary Mammary Organoid Model of Lactation and Involution

Authors

SUMBAL, Jakub (203 Czech Republic, belonging to the institution), Aurelie CHICHE (250 France), Elsa CHARIFOU (250 France), Zuzana KOLEDOVÁ (703 Slovakia, guarantor, belonging to the institution) and Han LI (250 France)

Edition

Frontiers in Cell and Developmental Biology, Lausanne, Frontiers Media S.A. 2020, 2296-634X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10605 Developmental biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.684

RIV identification code

RIV/00216224:14110/20:00116164

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fcell.2020.00068

UT WoS

000525631100001

Keywords in English

3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin

Abstract

V originále

Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.

Links

MUNI/A/1382/2019, interní kód MU

Name: Zdroje pro tkáňové inženýrství 10 (Acronym: TissueEng 10)

Investor: Masaryk University, Category A

MUNI/A/1565/2018, interní kód MU

Name: Zdroje pro tkáňové inženýrství 9 (Acronym: TissueEng 9)

Investor: Masaryk University, Category A

MUNI/G/1446/2018, interní kód MU

Name: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects

Citovat

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ and Han LI. Primary Mammary Organoid Model of Lactation and Involution. Frontiers in Cell and Developmental Biology. Lausanne: Frontiers Media S.A., 2020, vol. 8, MAR 2020, p. 1-13. ISSN 2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2020.00068.

@article{1673739,
   author = {Sumbal, Jakub and Chiche, Aurelie and Charifou, Elsa and Koledová, Zuzana and Li, Han},
   article_location = {Lausanne},
   article_number = {MAR 2020},
   doi = {http://dx.doi.org/10.3389/fcell.2020.00068},
   keywords = {3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {Primary Mammary Organoid Model of Lactation and Involution},
   url = {https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full},
   volume = {8},
   year = {2020}
}

TY  - JOUR
ID  - 1673739
AU  - Sumbal, Jakub - Chiche, Aurelie - Charifou, Elsa - Koledová, Zuzana - Li, Han
PY  - 2020
TI  - Primary Mammary Organoid Model of Lactation and Involution
JF  - Frontiers in Cell and Developmental Biology
VL  - 8
IS  - MAR 2020
SP  - 1-13
EP  - 1-13
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - 3D culture
KW  - fibroblast growth factor 2
KW  - involution
KW  - lactation
KW  - mammary gland
KW  - milk production
KW  - organoid
KW  - prolactin
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
L2  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
N2  - Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
ER  -

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ and Han LI. Primary Mammary Organoid Model of Lactation and Involution. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2020, vol.~8, MAR 2020, p.~1-13. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2020.00068.

Detailed Information on Publication Record