J 2021

Effects of implanting a long-term left ventricle assist device on post-transplant outcomes

BEDANOVA, Helena, Michal PAZDERNIK, Michal SONKA, Chen ZHI, Jan KREJČÍ et. al.

Basic information

Original name

Effects of implanting a long-term left ventricle assist device on post-transplant outcomes

Authors

BEDANOVA, Helena (203 Czech Republic), Michal PAZDERNIK (203 Czech Republic), Michal SONKA (203 Czech Republic), Chen ZHI (840 United States of America), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Petr DOBŠÁK (203 Czech Republic, guarantor, belonging to the institution) and Petr NEMEC (203 Czech Republic)

Edition

International Journal of Artificial Organs, London, SAGE PUBLICATIONS LTD, 2021, 0391-3988

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30213 Transplantation

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.631

RIV identification code

RIV/00216224:14110/21:00120664

Organization unit

Faculty of Medicine

DOI

UT WoS

000534504600001

Keywords in English

Heart transplantation; left ventricle assist device; early post-operative complications; survival

Tags

Tags

International impact, Reviewed
Změněno: 6/2/2023 12:27, Mgr. Tereza Miškechová

Abstract

V originále

Background: An increasing number of patients are receiving left ventricle assist devices as a bridge to heart transplantation. The aim of this study was to determine the difference between patients who received transplants from a left ventricle assist device and those who underwent heart transplantation without a prior left ventricle assist device implantation. Material and methods: The study included patients who underwent heart transplantation in our institute between January 2010 and November 2018. The following clinical variables were evaluated: donor characteristics, patient's pre-transplant demographical data, post-transplant data, and patient survival. Cardiac allograft vasculopathy progression was prospectively examined (after 1 month and 12 months after heart transplantation) by coronary optical coherence tomography. We were interested in the difference in 1- and 5-year survival between the left ventricle assist device and non-left ventricle assist device groups. Results: A total of 248 patients were identified; out of them, 48 patients received a left ventricle assist device before heart transplantation, whereas 200 had transplants with no prior left ventricle assist device implantation. There were no significant differences in any donor characteristics. The mean duration of cardiopulmonary bypass time in the non-left ventricle assist device group was 156 versus 175 min in the left ventricle assist device group (p = 0.009), blood loss was 650 versus 1045 mL (p < 0.001), the need to implant an extracorporeal membrane oxygenation was 10% versus 23% (p = 0.02). There was no difference in cardiac allograft vasculopathy progression between the groups 1 year after heart transplantation (p = 0.528). The 1- and 5-year survival, according to Kaplan-Meier, was 80% and 70% in the left ventricle assist device group, compared to 80% and 73%, respectively, in the non-left ventricle assist device group (Log-rank test: p = 0.945). Conclusion: Our results indicate that patients undergoing heart transplantation from left ventricle assist devices suffer significantly more from intraoperative and post-operative complications; however, only insignificant cardiac allograft vasculopathy progression and survival differences between the two groups were observed.