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@article{1673747,
author = {Bedanova, Helena and Pazdernik, Michal and Sonka, Michal and Zhi, Chen and Krejčí, Jan and Nováková, Marie and Dobšák, Petr and Nemec, Petr},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1177/0391398820914626},
keywords = {Heart transplantation; left ventricle assist device; early post-operative complications; survival},
language = {eng},
issn = {0391-3988},
journal = {International Journal of Artificial Organs},
title = {Effects of implanting a long-term left ventricle assist device on post-transplant outcomes},
url = {https://journals.sagepub.com/doi/10.1177/0391398820914626},
volume = {44},
year = {2021}
}
TY - JOUR
ID - 1673747
AU - Bedanova, Helena - Pazdernik, Michal - Sonka, Michal - Zhi, Chen - Krejčí, Jan - Nováková, Marie - Dobšák, Petr - Nemec, Petr
PY - 2021
TI - Effects of implanting a long-term left ventricle assist device on post-transplant outcomes
JF - International Journal of Artificial Organs
VL - 44
IS - 1
SP - 39-45
EP - 39-45
PB - SAGE PUBLICATIONS LTD
SN - 03913988
KW - Heart transplantation
KW - left ventricle assist device
KW - early post-operative complications
KW - survival
UR - https://journals.sagepub.com/doi/10.1177/0391398820914626
L2 - https://journals.sagepub.com/doi/10.1177/0391398820914626
N2 - Background: An increasing number of patients are receiving left ventricle assist devices as a bridge to heart transplantation. The aim of this study was to determine the difference between patients who received transplants from a left ventricle assist device and those who underwent heart transplantation without a prior left ventricle assist device implantation. Material and methods: The study included patients who underwent heart transplantation in our institute between January 2010 and November 2018. The following clinical variables were evaluated: donor characteristics, patient's pre-transplant demographical data, post-transplant data, and patient survival. Cardiac allograft vasculopathy progression was prospectively examined (after 1 month and 12 months after heart transplantation) by coronary optical coherence tomography. We were interested in the difference in 1- and 5-year survival between the left ventricle assist device and non-left ventricle assist device groups. Results: A total of 248 patients were identified; out of them, 48 patients received a left ventricle assist device before heart transplantation, whereas 200 had transplants with no prior left ventricle assist device implantation. There were no significant differences in any donor characteristics. The mean duration of cardiopulmonary bypass time in the non-left ventricle assist device group was 156 versus 175 min in the left ventricle assist device group (p = 0.009), blood loss was 650 versus 1045 mL (p < 0.001), the need to implant an extracorporeal membrane oxygenation was 10% versus 23% (p = 0.02). There was no difference in cardiac allograft vasculopathy progression between the groups 1 year after heart transplantation (p = 0.528). The 1- and 5-year survival, according to Kaplan-Meier, was 80% and 70% in the left ventricle assist device group, compared to 80% and 73%, respectively, in the non-left ventricle assist device group (Log-rank test: p = 0.945). Conclusion: Our results indicate that patients undergoing heart transplantation from left ventricle assist devices suffer significantly more from intraoperative and post-operative complications; however, only insignificant cardiac allograft vasculopathy progression and survival differences between the two groups were observed.
ER -
BEDANOVA, Helena, Michal PAZDERNIK, Michal SONKA, Chen ZHI, Jan KREJČÍ, Marie NOVÁKOVÁ, Petr DOBŠÁK and Petr NEMEC. Effects of implanting a long-term left ventricle assist device on post-transplant outcomes. \textit{International Journal of Artificial Organs}. London: SAGE PUBLICATIONS LTD, 2021, vol.~44, No~1, p.~39-45. ISSN~0391-3988. Available from: https://dx.doi.org/10.1177/0391398820914626.
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