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@article{1673770,
author = {Krutova, Marcela and Capek, Vaclav and Nycova, Elka and Vojackova, Sabina and Balejova, Magda and Geigerova, Lenka and Tejkalová, Renata and Havlinova, Lenka and Vagnerova, Iva and Cermak, Pavel and Ryskova, Lenka and Jezek, Petr and Zamazalova, Dana and Vesela, Denisa and Kucharova, Alice and Nemcova, Dana and Curdova, Martina and Nyc, Otakar and Drevinek, Pavel},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s13756-020-00765-y},
keywords = {Clostridium difficileinfection; Clostridioides difficileinfection; Czech Republic; PCR ribotype 001; PCR ribotype 176; Moxifloxacin; Mortality},
language = {eng},
issn = {2047-2994},
journal = {ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL},
title = {The association of a reduced susceptibility to moxifloxacin in causativeClostridium(Clostridioides)difficilestrain with the clinical outcome of patients},
url = {https://aricjournal.biomedcentral.com/track/pdf/10.1186/s13756-020-00765-y},
volume = {9},
year = {2020}
}
TY - JOUR
ID - 1673770
AU - Krutova, Marcela - Capek, Vaclav - Nycova, Elka - Vojackova, Sabina - Balejova, Magda - Geigerova, Lenka - Tejkalová, Renata - Havlinova, Lenka - Vagnerova, Iva - Cermak, Pavel - Ryskova, Lenka - Jezek, Petr - Zamazalova, Dana - Vesela, Denisa - Kucharova, Alice - Nemcova, Dana - Curdova, Martina - Nyc, Otakar - Drevinek, Pavel
PY - 2020
TI - The association of a reduced susceptibility to moxifloxacin in causativeClostridium(Clostridioides)difficilestrain with the clinical outcome of patients
JF - ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
VL - 9
IS - 1
SP - 1-7
EP - 1-7
PB - BMC
SN - 20472994
KW - Clostridium difficileinfection
KW - Clostridioides difficileinfection
KW - Czech Republic
KW - PCR ribotype 001
KW - PCR ribotype 176
KW - Moxifloxacin
KW - Mortality
UR - https://aricjournal.biomedcentral.com/track/pdf/10.1186/s13756-020-00765-y
L2 - https://aricjournal.biomedcentral.com/track/pdf/10.1186/s13756-020-00765-y
N2 - Objectives To investigate the relationship betweenClostridium (Clostridioides) difficilestrain characteristics andC. difficileinfection (CDI) outcome. Methods Between October and December 2017, 16 hospitals collected epidemiological data according to the European Centre for Disease Prevention and Control (ECDC) surveillance protocol for CDI.C. difficileisolates were characterized by ribotyping, toxin genes detection and antibiotic susceptibility testing to metronidazole, vancomycin and moxifloxacin. Results The overall mean CDI incidence density was 4.5 [95% CI 3.6-5.3] cases per 10,000 patient-days. From the 433 CDI cases, 330 (76.2%) were healthcare-associated, 52 (12.0%) cases were community-associated or of unknown origin and 51 (11.8%) CDI cases recurrent; a complicated course of CDI was reported in 65 cases (15.0%). Eighty-eight (20.3%) of patients died and 59 of them within 30 days after the CDI diagnosis. From the 379C. difficileisolates, the most prevalent PCR ribotypes were 001 (n = 127, 33.5%) and 176 (n = 44, 11.6%). A total of 186 (49.1%) isolates showed a reduced susceptibility to moxifloxacin (> 4 mg/L) and 96.4% of them had Thr82Ile in the GyrA. Nineteen isolates revealed reduced susceptibility to metronidazole and two isolates to vancomycin (> 2 mg/L). A fatal outcome was associated with a reduced susceptibility to moxifloxacin, the advanced age of the patients and a complicated course of CDI (p<0.05). No association between ribotype, binary toxin and a reduced susceptibility to moxifloxacin and complicated course or recurrent CDI was found. Conclusions A reduced susceptibility to moxifloxacin, in causativeC. difficilestrains was associated with fatal outcome of the patients, therefore it is an important marker in surveillance of CDI.
ER -
KRUTOVA, Marcela, Vaclav CAPEK, Elka NYCOVA, Sabina VOJACKOVA, Magda BALEJOVA, Lenka GEIGEROVA, Renata TEJKALOVÁ, Lenka HAVLINOVA, Iva VAGNEROVA, Pavel CERMAK, Lenka RYSKOVA, Petr JEZEK, Dana ZAMAZALOVA, Denisa VESELA, Alice KUCHAROVA, Dana NEMCOVA, Martina CURDOVA, Otakar NYC and Pavel DREVINEK. The association of a reduced susceptibility to moxifloxacin in causativeClostridium(Clostridioides)difficilestrain with the clinical outcome of patients. \textit{ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL}. LONDON: BMC, 2020, vol.~9, No~1, p.~1-7. ISSN~2047-2994. Available from: https://dx.doi.org/10.1186/s13756-020-00765-y.
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