J 2020

The association of a reduced susceptibility to moxifloxacin in causativeClostridium(Clostridioides)difficilestrain with the clinical outcome of patients

KRUTOVA, Marcela, Vaclav CAPEK, Elka NYCOVA, Sabina VOJACKOVA, Magda BALEJOVA et. al.

Basic information

Original name

The association of a reduced susceptibility to moxifloxacin in causativeClostridium(Clostridioides)difficilestrain with the clinical outcome of patients

Authors

KRUTOVA, Marcela (203 Czech Republic), Vaclav CAPEK (203 Czech Republic), Elka NYCOVA (203 Czech Republic), Sabina VOJACKOVA (203 Czech Republic), Magda BALEJOVA (203 Czech Republic), Lenka GEIGEROVA (203 Czech Republic), Renata TEJKALOVÁ (203 Czech Republic, belonging to the institution), Lenka HAVLINOVA (203 Czech Republic), Iva VAGNEROVA (203 Czech Republic), Pavel CERMAK (203 Czech Republic), Lenka RYSKOVA (203 Czech Republic), Petr JEZEK (203 Czech Republic), Dana ZAMAZALOVA (203 Czech Republic), Denisa VESELA (203 Czech Republic), Alice KUCHAROVA (203 Czech Republic), Dana NEMCOVA (203 Czech Republic), Martina CURDOVA (203 Czech Republic), Otakar NYC (203 Czech Republic) and Pavel DREVINEK (203 Czech Republic)

Edition

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, LONDON, BMC, 2020, 2047-2994

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10606 Microbiology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.887

RIV identification code

RIV/00216224:14110/20:00116176

Organization unit

Faculty of Medicine

UT WoS

000552013900002

Keywords in English

Clostridium difficileinfection; Clostridioides difficileinfection; Czech Republic; PCR ribotype 001; PCR ribotype 176; Moxifloxacin; Mortality

Tags

Tags

International impact, Reviewed
Změněno: 10/8/2020 13:07, Mgr. Tereza Miškechová

Abstract

V originále

Objectives To investigate the relationship betweenClostridium (Clostridioides) difficilestrain characteristics andC. difficileinfection (CDI) outcome. Methods Between October and December 2017, 16 hospitals collected epidemiological data according to the European Centre for Disease Prevention and Control (ECDC) surveillance protocol for CDI.C. difficileisolates were characterized by ribotyping, toxin genes detection and antibiotic susceptibility testing to metronidazole, vancomycin and moxifloxacin. Results The overall mean CDI incidence density was 4.5 [95% CI 3.6-5.3] cases per 10,000 patient-days. From the 433 CDI cases, 330 (76.2%) were healthcare-associated, 52 (12.0%) cases were community-associated or of unknown origin and 51 (11.8%) CDI cases recurrent; a complicated course of CDI was reported in 65 cases (15.0%). Eighty-eight (20.3%) of patients died and 59 of them within 30 days after the CDI diagnosis. From the 379C. difficileisolates, the most prevalent PCR ribotypes were 001 (n = 127, 33.5%) and 176 (n = 44, 11.6%). A total of 186 (49.1%) isolates showed a reduced susceptibility to moxifloxacin (> 4 mg/L) and 96.4% of them had Thr82Ile in the GyrA. Nineteen isolates revealed reduced susceptibility to metronidazole and two isolates to vancomycin (> 2 mg/L). A fatal outcome was associated with a reduced susceptibility to moxifloxacin, the advanced age of the patients and a complicated course of CDI (p<0.05). No association between ribotype, binary toxin and a reduced susceptibility to moxifloxacin and complicated course or recurrent CDI was found. Conclusions A reduced susceptibility to moxifloxacin, in causativeC. difficilestrains was associated with fatal outcome of the patients, therefore it is an important marker in surveillance of CDI.