In connection with the editorial of Mallineni et al. 2020 on the coronavirus disease (COVID-19) characteristics in children, we aim to demonstrate the emerging Pediatric Multi-system Inflammatory Syndrome Temporally Associated with SARS-COV-2 (PMIS-TS) from oral health professionals perspective. The epidemiological burden of COVID-19 in children was unexplainably lower than adults; therefore, it was predicted that the clinical course differs between children and adults, such hypothesis was confirmed by the surging cases of PMIS-TS.