MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA, Peter SABAKA, Rachele CICCOCIOPPO, Luis RODRIGO, Peter KRUŽLIAK and Peter MIKOLAJCIK. Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy. Clinical and Experimental Medicine. Milan: SPRINGER-VERLAG ITALIA SRL, 2021, vol. 21, No 2, p. 195-204. ISSN 1591-8890. Available from: https://dx.doi.org/10.1007/s10238-020-00649-w. |
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@article{1673997, author = {Mersakova, Sandra and Lasabova, Zora and Strnadel, Jan and Kalman, Michal and Gabonova, Eva and Sabaka, Peter and Ciccocioppo, Rachele and Rodrigo, Luis and Kružliak, Peter and Mikolajcik, Peter}, article_location = {Milan}, article_number = {2}, doi = {http://dx.doi.org/10.1007/s10238-020-00649-w}, keywords = {Colorectal cancer (CRC); Genomic profile; Immune cells; Immunotherapy}, language = {eng}, issn = {1591-8890}, journal = {Clinical and Experimental Medicine}, title = {Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy}, url = {https://link.springer.com/article/10.1007/s10238-020-00649-w}, volume = {21}, year = {2021} }
TY - JOUR ID - 1673997 AU - Mersakova, Sandra - Lasabova, Zora - Strnadel, Jan - Kalman, Michal - Gabonova, Eva - Sabaka, Peter - Ciccocioppo, Rachele - Rodrigo, Luis - Kružliak, Peter - Mikolajcik, Peter PY - 2021 TI - Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy JF - Clinical and Experimental Medicine VL - 21 IS - 2 SP - 195-204 EP - 195-204 PB - SPRINGER-VERLAG ITALIA SRL SN - 15918890 KW - Colorectal cancer (CRC) KW - Genomic profile KW - Immune cells KW - Immunotherapy UR - https://link.springer.com/article/10.1007/s10238-020-00649-w L2 - https://link.springer.com/article/10.1007/s10238-020-00649-w N2 - Colorectal cancer (CRC) is one of the leading cancers in both genders. TNM staging system is still the most commonly used tumor classification and prognostic system. The disadvantage of TNM is that the prognostic information it provides is incomplete, and patients with the same histological tumor stages may differ significantly in the clinical outcome. Therefore, the identification of new prognostic parameters is crucial. The carcinogenic process that gives rise to an individual tumor is unique and tumor microenviroment should be taken into consideration. In CRC, T-cell infiltration is not homogenous, and recent studies are mostly focusing on memory T-cells and CD8 cells in predicting disease-free survival (DFS) and overall survival (OS). It seems that DFS and OS are not only dependent on microsatellite instable or stable status but mostly on the levels of expression of the immune signatures. Also, patients with high infiltration of cytotoxic and memory cells have significantly better outcome. This review consolidates current knowledge and recent research about importance of immune-cell-associated proteins, specific gene profiles of immune cells and immunotherapy in CRC. We also discussed cell-specific signatures in cancer treatment. ER -
MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA, Peter SABAKA, Rachele CICCOCIOPPO, Luis RODRIGO, Peter KRUŽLIAK and Peter MIKOLAJCIK. Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy. \textit{Clinical and Experimental Medicine}. Milan: SPRINGER-VERLAG ITALIA SRL, 2021, vol.~21, No~2, p.~195-204. ISSN~1591-8890. Available from: https://dx.doi.org/10.1007/s10238-020-00649-w.
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