| MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA, Peter SABAKA, Rachele CICCOCIOPPO, Luis RODRIGO, Peter KRUŽLIAK and Peter MIKOLAJCIK. Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy. Clinical and Experimental Medicine. Milan: SPRINGER-VERLAG ITALIA SRL, 2021, vol. 21, No 2, p. 195-204. ISSN 1591-8890. Available from: https://dx.doi.org/10.1007/s10238-020-00649-w. |
Other formats:
BibTeX
LaTeX
RIS
@article{1673997,
author = {Mersakova, Sandra and Lasabova, Zora and Strnadel, Jan and Kalman, Michal and Gabonova, Eva and Sabaka, Peter and Ciccocioppo, Rachele and Rodrigo, Luis and Kružliak, Peter and Mikolajcik, Peter},
article_location = {Milan},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s10238-020-00649-w},
keywords = {Colorectal cancer (CRC); Genomic profile; Immune cells; Immunotherapy},
language = {eng},
issn = {1591-8890},
journal = {Clinical and Experimental Medicine},
title = {Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy},
url = {https://link.springer.com/article/10.1007/s10238-020-00649-w},
volume = {21},
year = {2021}
}
TY - JOUR
ID - 1673997
AU - Mersakova, Sandra - Lasabova, Zora - Strnadel, Jan - Kalman, Michal - Gabonova, Eva - Sabaka, Peter - Ciccocioppo, Rachele - Rodrigo, Luis - Kružliak, Peter - Mikolajcik, Peter
PY - 2021
TI - Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy
JF - Clinical and Experimental Medicine
VL - 21
IS - 2
SP - 195-204
EP - 195-204
PB - SPRINGER-VERLAG ITALIA SRL
SN - 15918890
KW - Colorectal cancer (CRC)
KW - Genomic profile
KW - Immune cells
KW - Immunotherapy
UR - https://link.springer.com/article/10.1007/s10238-020-00649-w
L2 - https://link.springer.com/article/10.1007/s10238-020-00649-w
N2 - Colorectal cancer (CRC) is one of the leading cancers in both genders. TNM staging system is still the most commonly used tumor classification and prognostic system. The disadvantage of TNM is that the prognostic information it provides is incomplete, and patients with the same histological tumor stages may differ significantly in the clinical outcome. Therefore, the identification of new prognostic parameters is crucial. The carcinogenic process that gives rise to an individual tumor is unique and tumor microenviroment should be taken into consideration. In CRC, T-cell infiltration is not homogenous, and recent studies are mostly focusing on memory T-cells and CD8 cells in predicting disease-free survival (DFS) and overall survival (OS). It seems that DFS and OS are not only dependent on microsatellite instable or stable status but mostly on the levels of expression of the immune signatures. Also, patients with high infiltration of cytotoxic and memory cells have significantly better outcome. This review consolidates current knowledge and recent research about importance of immune-cell-associated proteins, specific gene profiles of immune cells and immunotherapy in CRC. We also discussed cell-specific signatures in cancer treatment.
ER -
MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA, Peter SABAKA, Rachele CICCOCIOPPO, Luis RODRIGO, Peter KRUŽLIAK and Peter MIKOLAJCIK. Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy. \textit{Clinical and Experimental Medicine}. Milan: SPRINGER-VERLAG ITALIA SRL, 2021, vol.~21, No~2, p.~195-204. ISSN~1591-8890. Available from: https://dx.doi.org/10.1007/s10238-020-00649-w.
|
