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@article{1674065,
author = {ŠprlákováandPuková, Andrea and Štouračová, Alena and Repko, Martin and Koriťáková, Eva and Tintěra, Jaroslav and Dostál, Marek and Otaševič, Tomáš},
article_location = {New York},
article_number = {8},
doi = {http://dx.doi.org/10.1016/j.acra.2020.05.030},
keywords = {Cartilage; Magnetic resonance imaging; Microfracture; Autologous matrix-induced chondrogenesis},
language = {eng},
issn = {1076-6332},
journal = {Academic Radiology},
title = {Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1076633220303378},
volume = {28},
year = {2021}
}
TY - JOUR
ID - 1674065
AU - Šprláková-Puková, Andrea - Štouračová, Alena - Repko, Martin - Koriťáková, Eva - Tintěra, Jaroslav - Dostál, Marek - Otaševič, Tomáš
PY - 2021
TI - Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants
JF - Academic Radiology
VL - 28
IS - 8
SP - 1133-1141
EP - 1133-1141
PB - Elsevier
SN - 10766332
KW - Cartilage
KW - Magnetic resonance imaging
KW - Microfracture
KW - Autologous matrix-induced chondrogenesis
UR - https://www.sciencedirect.com/science/article/abs/pii/S1076633220303378
N2 - Rationale and Objectives: This study's aims were to depict changes in cartilage quality after surgical intervention using magnetic reso-nance (MR) examination and in content of glycosaminoglycans chains (GAGs) after two types of surgeries -chondral defect treatment by microfractures and scaffold implantation in combination with microfractures. Materials and Methods: Twenty-five patients were studied: 14 with implants, 11 with microfractures. MR examination was made before surgery and 6, 12, and 18 months thereafter. Qualitative changes in cartilage were observed by means of delayed gadolinium enhanced magnetic resonance imaging of cartilage sequence using Gd-DTPA2-and Gd-DOTA. In each examination, GAGs content was deter-mined at three locations: the defect, its surroundings, and a non-load-bearing reference area. Results: Measured indices showed no statistically significant differences in changes within the defect area when comparing the two treat-ment types at individual time points of 6, 12, and 18 months. In the case of microfracture treatment, more substantial decrease in GAGs concentration occurred at month 6, whereas the greatest decline occurred at month 12 when using an implant. Change in GAGs content and decline in cartilage quality were substantial also in the reference area and close surroundings. Conclusions: Hyaline cartilage behaves as a unified whole, and change in GAGs content was marked also in locations with no morpho-logical damage. Over the monitored period, no statistically significant difference between treatment types was noted as measured by GAGs content in the defect or its close surroundings. dGEMRIC is suitable for monitoring cartilage quality even if use of Gd-DTPA2-is not possible, because comparable results were achieved using Gd-DOTA.
ER -
ŠPRLÁKOVÁ-PUKOVÁ, Andrea, Alena ŠTOURAČOVÁ, Martin REPKO, Eva KORIŤÁKOVÁ, Jaroslav TINTĚRA, Marek DOSTÁL and Tomáš OTAŠEVIČ. Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants. \textit{Academic Radiology}. New York: Elsevier, 2021, vol.~28, No~8, p.~1133-1141. ISSN~1076-6332. Available from: https://dx.doi.org/10.1016/j.acra.2020.05.030.
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