No Evidence of Persistence or Inheritance of Mitochondrial DNA
Copy Number in Holocaust Survivors and Their Descendants

J 2020

No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants

CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS et. al.

Basic information

Original name

No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants

Authors

CAI, Na, Monika FŇAŠKOVÁ (203 Czech Republic, belonging to the institution), Klára KONEČNÁ (203 Czech Republic, belonging to the institution), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Jiří FAJKUS (203 Czech Republic, belonging to the institution), Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

FRONTIERS IN GENETICS, LAUSANNE, FRONTIERS MEDIA SA, 2020, 1664-8021

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30101 Human genetics

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.599

RIV identification code

RIV/00216224:14740/20:00116207

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3389/fgene.2020.00087

UT WoS

000525236500001

Keywords in English

mitochondrial DNA; posttraumatic stress disorder; copy number variation; quantitative PCR; Holocaust-psychic trauma

Abstract

V originále

Mitochondrial DNA copy number has been previously shown to be elevated with severe and chronic stress, as well as stress-related pathology like Major Depressive Disorder (MDD) and post-traumatic stress disorder (PTSD). While experimental data point to likely recovery of mtDNA copy number changes after the stressful event, time needed for full recovery and whether it can be achieved are still unknown. Further, while it has been shown that stress-related mtDNA elevation affects multiple tissues, its specific consequences for oogenesis and maternal inheritance of mtDNA has never been explored. In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, though that does not rule out effects in other tissues or mitigating mechanism for such changes.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV18-04-00559, research and development project

Name: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministry of Health of the CR, Neurobiological and psychological markers of reaction to extreme stress and its impact on offspring - three generation study of holocaust survivors and their offspring

Citovat

CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS, Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS and Ivan REKTOR. No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants. FRONTIERS IN GENETICS. LAUSANNE: FRONTIERS MEDIA SA, 2020, vol. 11, 03 March 2020, p. 87-98. ISSN 1664-8021. Available from: https://dx.doi.org/10.3389/fgene.2020.00087.

@article{1674167,
   author = {Cai, Na and Fňašková, Monika and Konečná, Klára and Fojtová, Miloslava and Fajkus, Jiří and Coomber, Eve and Watt, Stephen and Soranzo, Nicole and Preiss, Marek and Rektor, Ivan},
   article_location = {LAUSANNE},
   article_number = {03 March 2020},
   doi = {http://dx.doi.org/10.3389/fgene.2020.00087},
   keywords = {mitochondrial DNA; posttraumatic stress disorder; copy number variation; quantitative PCR; Holocaust-psychic trauma},
   language = {eng},
   issn = {1664-8021},
   journal = {FRONTIERS IN GENETICS},
   title = {No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants},
   url = {https://pubmed.ncbi.nlm.nih.gov/32211017/},
   volume = {11},
   year = {2020}
}

TY  - JOUR
ID  - 1674167
AU  - Cai, Na - Fňašková, Monika - Konečná, Klára - Fojtová, Miloslava - Fajkus, Jiří - Coomber, Eve - Watt, Stephen - Soranzo, Nicole - Preiss, Marek - Rektor, Ivan
PY  - 2020
TI  - No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants
JF  - FRONTIERS IN GENETICS
VL  - 11
IS  - 03 March 2020
SP  - 87
EP  - 87
PB  - FRONTIERS MEDIA SA
SN  - 16648021
KW  - mitochondrial DNA
KW  - posttraumatic stress disorder
KW  - copy number variation
KW  - quantitative PCR
KW  - Holocaust-psychic trauma
UR  - https://pubmed.ncbi.nlm.nih.gov/32211017/
L2  - https://pubmed.ncbi.nlm.nih.gov/32211017/
N2  - Mitochondrial DNA copy number has been previously shown to be elevated with severe and chronic stress, as well as stress-related pathology like Major Depressive Disorder (MDD) and post-traumatic stress disorder (PTSD). While experimental data point to likely recovery of mtDNA copy number changes after the stressful event, time needed for full recovery and whether it can be achieved are still unknown. Further, while it has been shown that stress-related mtDNA elevation affects multiple tissues, its specific consequences for oogenesis and maternal inheritance of mtDNA has never been explored. In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, though that does not rule out effects in other tissues or mitigating mechanism for such changes.
ER  -

CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS, Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS and Ivan REKTOR. No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants. \textit{FRONTIERS IN GENETICS}. LAUSANNE: FRONTIERS MEDIA SA, 2020, vol.~11, 03 March 2020, p.~87-98. ISSN~1664-8021. Available from: https://dx.doi.org/10.3389/fgene.2020.00087.

Detailed Information on Publication Record