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@article{1674500,
author = {Tsivgoulis, G. and Saqqur, M. and Sharma, V. K. and Brunser, A. and Eggers, J. and Mikulík, Robert and Katsanos, A. H. and Sergentanis, T. N. and Vadikolias, K. and Perren, F. and Rubiera, M. and Shahripour, R. B. and Nguyen, H. T. and MartinezandSanchez, P. and Safouris, A. and Heliopoulos, I. and Shuaib, A. and Derksen, C. and Voumvourakis, K. and Psaltopoulou, T. and Alexandrov, A. W. and Alexandrov, A. V.},
article_location = {SEOUL},
article_number = {1},
doi = {http://dx.doi.org/10.5853/jos.2019.01648},
keywords = {Thrombolysis; Stroke; Reperfusion; Outcomes},
language = {eng},
issn = {2287-6391},
journal = {JOURNAL OF STROKE},
title = {Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke},
url = {https://www.j-stroke.org/upload/pdf/jos-2019-01648.pdf},
volume = {22},
year = {2020}
}
TY - JOUR
ID - 1674500
AU - Tsivgoulis, G. - Saqqur, M. - Sharma, V. K. - Brunser, A. - Eggers, J. - Mikulík, Robert - Katsanos, A. H. - Sergentanis, T. N. - Vadikolias, K. - Perren, F. - Rubiera, M. - Shahripour, R. B. - Nguyen, H. T. - Martinez-Sanchez, P. - Safouris, A. - Heliopoulos, I. - Shuaib, A. - Derksen, C. - Voumvourakis, K. - Psaltopoulou, T. - Alexandrov, A. W. - Alexandrov, A. V.
PY - 2020
TI - Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
JF - JOURNAL OF STROKE
VL - 22
IS - 1
SP - „130-140+1“-„9“
EP - „130-140+1“-„9“
PB - KOREAN STROKE SOC
SN - 22876391
KW - Thrombolysis
KW - Stroke
KW - Reperfusion
KW - Outcomes
UR - https://www.j-stroke.org/upload/pdf/jos-2019-01648.pdf
L2 - https://www.j-stroke.org/upload/pdf/jos-2019-01648.pdf
N2 - Background and Purpose Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable. Methods We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FF0) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0-1 and 0-2 respectively. Results We enrolled 480 AIS patients (mean age 66 +/- 15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15). Patients with early recanalization (53% vs 10%) had significantly (P<0.001) higher rates of DCR at 2-hour (54% vs. 10%) and 24-hour (63% vs. 22%), 3-month FFO (67% vs. 28 %) and F1 (81% vs. 39%). Three-month mortality rates (6% vs. 17%) and distribution of 3-month mRS scores were significantly lower in the early recanalization group. After adjusting for potential confounders, early recanalization was independently associated with higher odds of 3-month FFO (odds ratio [011], 6.19; 95% confidence interval [CI], 3.88 to 9.88) and lower likelihood of 3-month mortality (OR, 0.34; 95% CI, 0.17 to 0.67). Onset to treatment time correlated to the elapsed time between tPA-bolus and recanalization (unstandardized linear regression coefficient, 0.13; 95% CI, 0.06 to 0.19). Conclusions Earlier tPA treatment after stroke onset is associated with faster tPA-induced recanalization. Earlier onset-to-recanalization time results in improved functional recovery and survival in AIS patients with proximal intracranial occlusions.
ER -
TSIVGOULIS, G., M. SAQQUR, V. K. SHARMA, A. BRUNSER, J. EGGERS, Robert MIKULÍK, A. H. KATSANOS, T. N. SERGENTANIS, K. VADIKOLIAS, F. PERREN, M. RUBIERA, R. B. SHAHRIPOUR, H. T. NGUYEN, P. MARTINEZ-SANCHEZ, A. SAFOURIS, I. HELIOPOULOS, A. SHUAIB, C. DERKSEN, K. VOUMVOURAKIS, T. PSALTOPOULOU, A. W. ALEXANDROV and A. V. ALEXANDROV. Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke. \textit{JOURNAL OF STROKE}. SEOUL: KOREAN STROKE SOC, 2020, vol.~22, No~1, p.~„130-140+1“-„9“, 20 pp. ISSN~2287-6391. Available from: https://dx.doi.org/10.5853/jos.2019.01648.
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