Autoimmune pancreatitis - An ongoing challenge

J 2020

Autoimmune pancreatitis - An ongoing challenge

BLAHO, Martin, Petr DÍTĚ, Lumír KUNOVSKÝ and Bohuslav KIANIČKA

Basic information

Original name

Autoimmune pancreatitis - An ongoing challenge

Authors

BLAHO, Martin (203 Czech Republic), Petr DÍTĚ (203 Czech Republic), Lumír KUNOVSKÝ (203 Czech Republic, belonging to the institution) and Bohuslav KIANIČKA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Advances in Medical Sciences, Bialystok, Medical Univ Bialystok, 2020, 1896-1126

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.287

RIV identification code

RIV/00216224:14110/20:00116220

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.advms.2020.07.002

UT WoS

000613505100022

Keywords in English

Autoimmune pancreatitis; Chronic pancreatitis; IgG4-related disease; Pancreatic insufficiency; Pancreatic cancer

Abstract

V originále

Autoimmune pancreatitis is a rare form of chronic pancreatitis. The first descriptions of the disease date back to the 1990s. Etiology is multifactorial, with the use of genetic, environmental and complex immunological mechanisms. It is classified into two subtypes. Type 1 is part of a group of diseases called IgG4-related disease. Clinically is autoimmune pancreatitis manifested by icterus and abdominal discomfort. It can rarely present as acute pancreatitis. There is also a completely asymptomatic form of the disease. The diagnosis is based on abnormalities in histology, imaging methods, serology, the involvement of other organs in relation to IgG4-related disease, and a significant positive response to corticosteroid therapy. Differential diagnosis between the focal form of autoimmune pancreatitis and pancreatic cancer can be complicated, with endosonography playing an important role. In the treatment, we use corticosteroids and other immunosuppressants including biological therapy. Patients with the asymptomatic disease should also be treated to prevent late complications and exocrine and endocrine insufficiency. In addition to drug treatment, endoscopic and/or surgical treatment may be necessary. Even after recovery, the disease can relapse. The relationship between autoimmune pancreatitis and malignancies has not been clearly confirmed. The goal of this review is to provide a comprehensive look at autoimmune pancreatitis and translate latest scientific knowledge into clinical practice.

Citovat

BLAHO, Martin, Petr DÍTĚ, Lumír KUNOVSKÝ and Bohuslav KIANIČKA. Autoimmune pancreatitis - An ongoing challenge. Advances in Medical Sciences. Bialystok: Medical Univ Bialystok, 2020, vol. 65, No 2, p. 403-408. ISSN 1896-1126. Available from: https://dx.doi.org/10.1016/j.advms.2020.07.002.

@article{1674503,
   author = {Blaho, Martin and Dítě, Petr and Kunovský, Lumír and Kianička, Bohuslav},
   article_location = {Bialystok},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.advms.2020.07.002},
   keywords = {Autoimmune pancreatitis; Chronic pancreatitis; IgG4-related disease; Pancreatic insufficiency; Pancreatic cancer},
   language = {eng},
   issn = {1896-1126},
   journal = {Advances in Medical Sciences},
   title = {Autoimmune pancreatitis - An ongoing challenge},
   url = {https://www.sciencedirect.com/science/article/pii/S1896112620300328?via%3Dihub},
   volume = {65},
   year = {2020}
}

TY  - JOUR
ID  - 1674503
AU  - Blaho, Martin - Dítě, Petr - Kunovský, Lumír - Kianička, Bohuslav
PY  - 2020
TI  - Autoimmune pancreatitis - An ongoing challenge
JF  - Advances in Medical Sciences
VL  - 65
IS  - 2
SP  - 403-408
EP  - 403-408
PB  - Medical Univ Bialystok
SN  - 18961126
KW  - Autoimmune pancreatitis
KW  - Chronic pancreatitis
KW  - IgG4-related disease
KW  - Pancreatic insufficiency
KW  - Pancreatic cancer
UR  - https://www.sciencedirect.com/science/article/pii/S1896112620300328?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1896112620300328?via%3Dihub
N2  - Autoimmune pancreatitis is a rare form of chronic pancreatitis. The first descriptions of the disease date back to the 1990s. Etiology is multifactorial, with the use of genetic, environmental and complex immunological mechanisms. It is classified into two subtypes. Type 1 is part of a group of diseases called IgG4-related disease. Clinically is autoimmune pancreatitis manifested by icterus and abdominal discomfort. It can rarely present as acute pancreatitis. There is also a completely asymptomatic form of the disease. The diagnosis is based on abnormalities in histology, imaging methods, serology, the involvement of other organs in relation to IgG4-related disease, and a significant positive response to corticosteroid therapy. Differential diagnosis between the focal form of autoimmune pancreatitis and pancreatic cancer can be complicated, with endosonography playing an important role. In the treatment, we use corticosteroids and other immunosuppressants including biological therapy. Patients with the asymptomatic disease should also be treated to prevent late complications and exocrine and endocrine insufficiency. In addition to drug treatment, endoscopic and/or surgical treatment may be necessary. Even after recovery, the disease can relapse. The relationship between autoimmune pancreatitis and malignancies has not been clearly confirmed. The goal of this review is to provide a comprehensive look at autoimmune pancreatitis and translate latest scientific knowledge into clinical practice.
ER  -

BLAHO, Martin, Petr DÍTĚ, Lumír KUNOVSKÝ and Bohuslav KIANIČKA. Autoimmune pancreatitis - An ongoing challenge. \textit{Advances in Medical Sciences}. Bialystok: Medical Univ Bialystok, 2020, vol.~65, No~2, p.~403-408. ISSN~1896-1126. Available from: https://dx.doi.org/10.1016/j.advms.2020.07.002.

Detailed Information on Publication Record