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@article{1674503,
author = {Blaho, Martin and Dítě, Petr and Kunovský, Lumír and Kianička, Bohuslav},
article_location = {Bialystok},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.advms.2020.07.002},
keywords = {Autoimmune pancreatitis; Chronic pancreatitis; IgG4-related disease; Pancreatic insufficiency; Pancreatic cancer},
language = {eng},
issn = {1896-1126},
journal = {Advances in Medical Sciences},
title = {Autoimmune pancreatitis - An ongoing challenge},
url = {https://www.sciencedirect.com/science/article/pii/S1896112620300328?via%3Dihub},
volume = {65},
year = {2020}
}
TY - JOUR
ID - 1674503
AU - Blaho, Martin - Dítě, Petr - Kunovský, Lumír - Kianička, Bohuslav
PY - 2020
TI - Autoimmune pancreatitis - An ongoing challenge
JF - Advances in Medical Sciences
VL - 65
IS - 2
SP - 403-408
EP - 403-408
PB - Medical Univ Bialystok
SN - 18961126
KW - Autoimmune pancreatitis
KW - Chronic pancreatitis
KW - IgG4-related disease
KW - Pancreatic insufficiency
KW - Pancreatic cancer
UR - https://www.sciencedirect.com/science/article/pii/S1896112620300328?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1896112620300328?via%3Dihub
N2 - Autoimmune pancreatitis is a rare form of chronic pancreatitis. The first descriptions of the disease date back to the 1990s. Etiology is multifactorial, with the use of genetic, environmental and complex immunological mechanisms. It is classified into two subtypes. Type 1 is part of a group of diseases called IgG4-related disease. Clinically is autoimmune pancreatitis manifested by icterus and abdominal discomfort. It can rarely present as acute pancreatitis. There is also a completely asymptomatic form of the disease. The diagnosis is based on abnormalities in histology, imaging methods, serology, the involvement of other organs in relation to IgG4-related disease, and a significant positive response to corticosteroid therapy. Differential diagnosis between the focal form of autoimmune pancreatitis and pancreatic cancer can be complicated, with endosonography playing an important role. In the treatment, we use corticosteroids and other immunosuppressants including biological therapy. Patients with the asymptomatic disease should also be treated to prevent late complications and exocrine and endocrine insufficiency. In addition to drug treatment, endoscopic and/or surgical treatment may be necessary. Even after recovery, the disease can relapse. The relationship between autoimmune pancreatitis and malignancies has not been clearly confirmed. The goal of this review is to provide a comprehensive look at autoimmune pancreatitis and translate latest scientific knowledge into clinical practice.
ER -
BLAHO, Martin, Petr DÍTĚ, Lumír KUNOVSKÝ and Bohuslav KIANIČKA. Autoimmune pancreatitis - An ongoing challenge. \textit{Advances in Medical Sciences}. Bialystok: Medical Univ Bialystok, vol.~65, No~2, p.~403-408. ISSN~1896-1126. doi:10.1016/j.advms.2020.07.002. 2020.
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