| PAZDERNIK, Michal, Dan WICHTERLE, Zhi CHEN, Helena BEDANOVA, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Peter STIAVNICKY, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Andreas WAHLE, Honghai ZHANG, Tomas KOVARNIK and Milan SONKA. Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. CLINICAL TRANSPLANTATION. HOBOKEN: WILEY, 2020, vol. 34, No 2, p. 1-9. ISSN 0902-0063. Available from: https://dx.doi.org/10.1111/ctr.13773. |
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@article{1674767,
author = {Pazdernik, Michal and Wichterle, Dan and Chen, Zhi and Bedanova, Helena and Kautzner, Josef and Melenovsky, Vojtech and Karmazin, Vladimir and Malek, Ivan and Stiavnicky, Peter and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Wahle, Andreas and Zhang, Honghai and Kovarnik, Tomas and Sonka, Milan},
article_location = {HOBOKEN},
article_number = {2},
doi = {http://dx.doi.org/10.1111/ctr.13773},
keywords = {beta blocker; cardiac allograft vasculopathy; heart rate; optical coherence tomography},
language = {eng},
issn = {0902-0063},
journal = {CLINICAL TRANSPLANTATION},
title = {Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis},
url = {https://onlinelibrary.wiley.com/doi/full/10.1111/ctr.13773},
volume = {34},
year = {2020}
}
TY - JOUR
ID - 1674767
AU - Pazdernik, Michal - Wichterle, Dan - Chen, Zhi - Bedanova, Helena - Kautzner, Josef - Melenovsky, Vojtech - Karmazin, Vladimir - Malek, Ivan - Stiavnicky, Peter - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Wahle, Andreas - Zhang, Honghai - Kovarnik, Tomas - Sonka, Milan
PY - 2020
TI - Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
JF - CLINICAL TRANSPLANTATION
VL - 34
IS - 2
SP - 1-9
EP - 1-9
PB - WILEY
SN - 09020063
KW - beta blocker
KW - cardiac allograft vasculopathy
KW - heart rate
KW - optical coherence tomography
UR - https://onlinelibrary.wiley.com/doi/full/10.1111/ctr.13773
L2 - https://onlinelibrary.wiley.com/doi/full/10.1111/ctr.13773
N2 - Introduction Heart rate slowing agents are frequently prescribed to manage heart transplant (HTx) patients with the assumption that higher heart rate is a risk factor in cardiovascular disease. Patients and Methods This prospective two-center study investigated early progression of cardiac allograft vasculopathy (CAV) in 116 HTx patients. Examinations by coronary optical coherence tomography and 24-hour ambulatory ECG monitoring were performed both at baseline (1 month after HTx) and during follow-up (12 months after HTx). Results During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area from 9.0 +/- 2.5 to 8.0 +/- 2.4 mm(2) (P < .001), and progression in mean intimal thickness (IT) from 106.5 +/- 40.4 to 130.1 +/- 53.0 mu m (P < .001). No significant relationship was observed between baseline and follow-up mean heart rates and IT progression (R = .02, P = .83; R = -.13, P = .18). We found a mild inverse association between beta-blocker dosage at 12 months and IT progression (R = -.20, P = .035). Conclusion Our study did not confirm a direct association between mean heart rate and progression of CAV. The role of beta blockers warrants further investigation, with our results indicating that they may play a protective role in early CAV development.
ER -
PAZDERNIK, Michal, Dan WICHTERLE, Zhi CHEN, Helena BEDANOVA, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Peter STIAVNICKY, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Andreas WAHLE, Honghai ZHANG, Tomas KOVARNIK and Milan SONKA. Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. \textit{CLINICAL TRANSPLANTATION}. HOBOKEN: WILEY, 2020, vol.~34, No~2, p.~1-9. ISSN~0902-0063. Available from: https://dx.doi.org/10.1111/ctr.13773.
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