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@article{1674861,
author = {Giallongo, Sebastiano and Řeháková, Daniela and Raffaele, Marco and Lo Re, Oriana and Koutná, Irena and Vinciguerra, Manlio},
article_location = {NEW ROCHELLE},
article_number = {4},
doi = {http://dx.doi.org/10.1089/ars.2019.7983},
keywords = {induced pluripotent stem cells (iPSCs); oxidative stress; DNA damage},
language = {eng},
issn = {1523-0864},
journal = {ANTIOXIDANTS & REDOX SIGNALING},
title = {Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation},
url = {https://www.liebertpub.com/doi/10.1089/ars.2019.7983},
volume = {34},
year = {2021}
}
TY - JOUR
ID - 1674861
AU - Giallongo, Sebastiano - Řeháková, Daniela - Raffaele, Marco - Lo Re, Oriana - Koutná, Irena - Vinciguerra, Manlio
PY - 2021
TI - Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation
JF - ANTIOXIDANTS & REDOX SIGNALING
VL - 34
IS - 4
SP - 335-349
EP - 335-349
PB - MARY ANN LIEBERT, INC
SN - 15230864
KW - induced pluripotent stem cells (iPSCs)
KW - oxidative stress
KW - DNA damage
UR - https://www.liebertpub.com/doi/10.1089/ars.2019.7983
L2 - https://www.liebertpub.com/doi/10.1089/ars.2019.7983
N2 - Significance:Since their discovery, induced pluripotent stem cells (iPSCs) had generated considerable interest in the scientific community for their great potential in regenerative medicine, disease modeling, and cell-based therapeutic approach, due to their unique characteristics of self-renewal and pluripotency. Recent Advances:Technological advances in iPSC genome-wide epigenetic profiling led to the elucidation of the epigenetic control of cellular identity during nuclear reprogramming. Moreover, iPSC physiology and metabolism are tightly regulated by oxidation-reduction events that mainly occur during the respiratory chain. In theory, iPSC-derived differentiated cells would be ideal for stem cell transplantation as autologous cells from donors, as the risks of rejection are minimal. Critical Issues:However, iPSCs experience high oxidative stress that, in turn, confers a high risk of increased genomic instability, which is most often linked to DNA repair deficiencies. Genomic instability has to be assessed before iPSCs can be used in therapeutic designs. Future Directions:This review will particularly focus on the links between redox balance and epigenetic modifications-in particular based on the histone variant macroH2A1-that determine DNA damage response in iPSCs and derived differentiated cells, and that might be exploited to decrease the teratogenic potential on iPSC transplantation.
ER -
GIALLONGO, Sebastiano, Daniela ŘEHÁKOVÁ, Marco RAFFAELE, Oriana LO RE, Irena KOUTNÁ and Manlio VINCIGUERRA. Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation. \textit{ANTIOXIDANTS \&{} REDOX SIGNALING}. NEW ROCHELLE: MARY ANN LIEBERT, INC, 2021, vol.~34, No~4, p.~335-349. ISSN~1523-0864. Available from: https://dx.doi.org/10.1089/ars.2019.7983.
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