Detailed Information on Publication Record
2021
Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation
GIALLONGO, Sebastiano, Daniela ŘEHÁKOVÁ, Marco RAFFAELE, Oriana LO RE, Irena KOUTNÁ et. al.Basic information
Original name
Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation
Authors
GIALLONGO, Sebastiano (380 Italy, belonging to the institution), Daniela ŘEHÁKOVÁ (203 Czech Republic, belonging to the institution), Marco RAFFAELE (380 Italy), Oriana LO RE (380 Italy), Irena KOUTNÁ (203 Czech Republic, belonging to the institution) and Manlio VINCIGUERRA (380 Italy, guarantor, belonging to the institution)
Edition
ANTIOXIDANTS & REDOX SIGNALING, NEW ROCHELLE, MARY ANN LIEBERT, INC, 2021, 1523-0864
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 7.468
RIV identification code
RIV/00216224:14110/21:00120673
Organization unit
Faculty of Medicine
UT WoS
000555879000001
Keywords in English
induced pluripotent stem cells (iPSCs); oxidative stress; DNA damage
Tags
International impact, Reviewed
Změněno: 24/10/2022 10:17, Mgr. Tereza Miškechová
Abstract
V originále
Significance:Since their discovery, induced pluripotent stem cells (iPSCs) had generated considerable interest in the scientific community for their great potential in regenerative medicine, disease modeling, and cell-based therapeutic approach, due to their unique characteristics of self-renewal and pluripotency. Recent Advances:Technological advances in iPSC genome-wide epigenetic profiling led to the elucidation of the epigenetic control of cellular identity during nuclear reprogramming. Moreover, iPSC physiology and metabolism are tightly regulated by oxidation-reduction events that mainly occur during the respiratory chain. In theory, iPSC-derived differentiated cells would be ideal for stem cell transplantation as autologous cells from donors, as the risks of rejection are minimal. Critical Issues:However, iPSCs experience high oxidative stress that, in turn, confers a high risk of increased genomic instability, which is most often linked to DNA repair deficiencies. Genomic instability has to be assessed before iPSCs can be used in therapeutic designs. Future Directions:This review will particularly focus on the links between redox balance and epigenetic modifications-in particular based on the histone variant macroH2A1-that determine DNA damage response in iPSCs and derived differentiated cells, and that might be exploited to decrease the teratogenic potential on iPSC transplantation.
Links
MUNI/A/1325/2020, interní kód MU |
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90128, large research infrastructures |
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