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@article{1675320,
author = {Šťastná, Eva and Částková, Klára and Ráheľ, Jozef},
article_location = {Basel},
article_number = {9},
doi = {http://dx.doi.org/10.3390/polym12091877},
keywords = {electrospinning; nanofibers; polycaprolactone; hydroxyapatite; tissue engineering; atmospheric pressure argon plasma},
language = {eng},
issn = {2073-4360},
journal = {Polymers},
title = {Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers},
url = {https://doi.org/10.3390/polym12091877},
volume = {12},
year = {2020}
}
TY - JOUR
ID - 1675320
AU - Šťastná, Eva - Částková, Klára - Ráheľ, Jozef
PY - 2020
TI - Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers
JF - Polymers
VL - 12
IS - 9
SP - 1-16
EP - 1-16
PB - MDPI
SN - 20734360
KW - electrospinning
KW - nanofibers
KW - polycaprolactone
KW - hydroxyapatite
KW - tissue engineering
KW - atmospheric pressure argon plasma
UR - https://doi.org/10.3390/polym12091877
L2 - https://doi.org/10.3390/polym12091877
N2 - Nanofibers are well known as a beneficial type of structure for tissue engineering. As a result of the high acquisition cost of the natural polymers and their environmentally problematic treatment (toxic dissolution agents), artificial polymers seem to be the better choice for medical use. In the present study, polycaprolactone nano-sized fibrous structures were prepared by the electrospinning method. The impact of material morphology (random or parallelly oriented fibers versus continuous layer) and the presence of a fraction of hydroxyapatite nanoparticles on cell proliferation was tested. In addition, the effect of improving the material wettability by a low temperature argon discharge plasma treatment was evaluated, too. We have shown that both hydroxyapatite particles as well as plasma surface treatment are beneficial for the cell proliferation. The significant impact of both influences was evident during the first 48 h of the test: the hydroxyapatite particles in polycaprolactone fibers accelerated the proliferation by 10% compared to the control, and the plasma-treated ones enhanced proliferation by 30%.
ER -
ŠŤASTNÁ, Eva, Klára ČÁSTKOVÁ a Jozef RÁHEĽ. Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers. \textit{Polymers}. Basel: MDPI, 2020, roč.~12, č.~9, s.~1-16. ISSN~2073-4360. Dostupné z: https://dx.doi.org/10.3390/polym12091877.
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