TROJÁK, Matej, David ŠAFRÁNEK, Lukrécia MERTOVÁ and Luboš BRIM. Executable Biochemical Space for Specification and Analysis of Biochemical Systems. In 7th Workshop on Hybrid Systems and Biology. 2020.
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Basic information
Original name Executable Biochemical Space for Specification and Analysis of Biochemical Systems
Authors TROJÁK, Matej, David ŠAFRÁNEK, Lukrécia MERTOVÁ and Luboš BRIM.
Edition 7th Workshop on Hybrid Systems and Biology, 2020.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 10201 Computer sciences, information science, bioinformatics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Informatics
Keywords in English systems biology; rule-based modelling; annotation
Tags International impact, Reviewed
Changed by Changed by: doc. RNDr. David Šafránek, Ph.D., učo 3159. Changed: 15/4/2021 11:40.
Abstract
We present a rule-based language called Biochemical Space Language (BCSL) as an integral part of a general framework called Comprehensive Modelling Platform, developed for comprehensive modelling in systems biology. The general goal of the platform is to respect the need for maintaining existing ODE models but allows to align them with a mechanistic rule-based description that is understandable by biologists, compact in size, executable in terms of allowing basic analysis tasks ensuring consistency of the description, and provides links to existing bioinformatics annotation databases. Such a comprehensive solution allows to support effort of modellers in building mathematical models that have clear biochemical meaning and can be easily integrated. Moreover, mechanistic descriptions can be later used as computational models having all advantages of rule-based modelling.
Links
GA15-11089S, research and development projectName: Získávání parametrů biologických modelů pomocí techniky ověřování modelů
Investor: Czech Science Foundation
MUNI/A/1050/2019, interní kód MUName: Rozsáhlé výpočetní systémy: modely, aplikace a verifikace IX (Acronym: SV-FI MAV IX)
Investor: Masaryk University, Category A
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