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@article{1676806,
author = {Cimflová, Petra and Volný, Ondřej and Mikulík, Robert and Tyshchenko, Bohdan and Belaskova, Silvie and Vinklarek, Jan and Červeňák, Vladimír and Křivka, Tomáš and Vaníček, Jiří and Krajina, Antonin},
article_location = {AMSTERDAM},
article_number = {9},
doi = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104978},
keywords = {Stroke imaging; Early ischemic changes; ASPECTS; e-ASPECTS; CT perfusion; RAPID},
language = {eng},
issn = {1052-3057},
journal = {JOURNAL OF STROKE & CEREBROVASCULAR DISEASES},
title = {Detection of ischemic changes on baseline multimodal computed tomography: expert reading vs. Brainomix and RAPID software},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1052305720303967},
volume = {29},
year = {2020}
}
TY - JOUR
ID - 1676806
AU - Cimflová, Petra - Volný, Ondřej - Mikulík, Robert - Tyshchenko, Bohdan - Belaskova, Silvie - Vinklarek, Jan - Červeňák, Vladimír - Křivka, Tomáš - Vaníček, Jiří - Krajina, Antonin
PY - 2020
TI - Detection of ischemic changes on baseline multimodal computed tomography: expert reading vs. Brainomix and RAPID software
JF - JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
VL - 29
IS - 9
SP - 1-10
EP - 1-10
PB - ELSEVIER SCIENCE BV
SN - 10523057
KW - Stroke imaging
KW - Early ischemic changes
KW - ASPECTS
KW - e-ASPECTS
KW - CT perfusion
KW - RAPID
UR - https://linkinghub.elsevier.com/retrieve/pii/S1052305720303967
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052305720303967
N2 - Purpose: The aim of the study was to compare the assessment of ischemic changes by expert reading and available automated software for non-contrast CT (NCCT) and CT perfusion on baseline multimodal imaging and demonstrate the accuracy for the final infarct prediction. Methods: Early ischemic changes were measured by ASPECTS on the baseline neuroimaging of consecutive patients with anterior circulation ischemic stroke. The presence of early ischemic changes was assessed a) on NCCT by two experienced raters, b) on NCCT by e-ASPECTS, and c) visually on derived CT perfusion maps (CBF<30%, Tmax>10s). Accuracy was calculated by comparing presence of final ischemic changes on 24-hour follow-up for each ASPECTS region and expressed as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The subanalysis for patients with successful recanalization was conducted. Results: Of 263 patients, 81 fulfilled inclusion criteria. Median baseline ASPECTS was 9 for all tested modalities. Accuracy was 0.76 for e-ASPECTS, 0.79 for consensus, 0.82 for CBF<30%, 0.80 for Tmax>10s. e-ASPECTS, consensus, CBF<30%, and Tmax>10s had sensitivity 0.41, 0.46, 0.49, 0.57, respectively; specificity 0.91, 0.93, 0.95, 0.91, respectively; PPV 0.66, 0.75, 0.82, 0.73, respectively; NPV 0.78, 0.80, 0.82, 0.83, respectively. Results did not differ in patients with and without successful recanalization. Conclusion: This study demonstrated high accuracy for the assessment of ischemic changes by different CT modalities with the best accuracy for CBF<30% and Tmax>10s. The use of automated software has a potential to improve the detection of ischemic changes. (c) 2020 Elsevier Inc. All rights reserved.
ER -
CIMFLOVÁ, Petra, Ondřej VOLNÝ, Robert MIKULÍK, Bohdan TYSHCHENKO, Silvie BELASKOVA, Jan VINKLAREK, Vladimír ČERVEŇÁK, Tomáš KŘIVKA, Jiří VANÍČEK and Antonin KRAJINA. Detection of ischemic changes on baseline multimodal computed tomography: expert reading vs. Brainomix and RAPID software. \textit{JOURNAL OF STROKE \&{}amp; CEREBROVASCULAR DISEASES}. AMSTERDAM: ELSEVIER SCIENCE BV, 2020, vol.~29, No~9, p.~1-10. ISSN~1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104978.
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