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@article{1677757,
author = {Toman, Ondřej and Hnátková, Kateřina and Smetana, Peter and Huster, Katharina M. and Šišáková, Martina and Barthel, Petra and Novotný, Tomáš and Schmidt, Georg and Malík, Marek},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-59480-8},
keywords = {physiologic heart rate dependency; PQ interval; sex differences},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Physiologic heart rate dependency of the PQ interval and its sex differences},
url = {https://www.nature.com/articles/s41598-020-59480-8},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1677757
AU - Toman, Ondřej - Hnátková, Kateřina - Smetana, Peter - Huster, Katharina M. - Šišáková, Martina - Barthel, Petra - Novotný, Tomáš - Schmidt, Georg - Malík, Marek
PY - 2020
TI - Physiologic heart rate dependency of the PQ interval and its sex differences
JF - Scientific Reports
VL - 10
IS - 1
SP - 1-17
EP - 1-17
PB - Nature Publishing Group
SN - 20452322
KW - physiologic heart rate dependency
KW - PQ interval
KW - sex differences
UR - https://www.nature.com/articles/s41598-020-59480-8
L2 - https://www.nature.com/articles/s41598-020-59480-8
N2 - On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 +/- 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 +/- 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 +/- 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 +/- 81.1 vs 65.4 +/- 64.3 seconds, respectively, p < 0.00001). P wave duration was even less rate dependent than the PQ interval (9 +/- 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 +/- 8.4 vs 110.2 +/- 7.9 ms, p < 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.
ER -
TOMAN, Ondřej, Kateřina HNÁTKOVÁ, Peter SMETANA, Katharina M. HUSTER, Martina ŠIŠÁKOVÁ, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT and Marek MALÍK. Physiologic heart rate dependency of the PQ interval and its sex differences. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, vol.~10, No~1, p.~1-17. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-59480-8.
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