Detailed Information on Publication Record
2020
Physiologic heart rate dependency of the PQ interval and its sex differences
TOMAN, Ondřej, Kateřina HNÁTKOVÁ, Peter SMETANA, Katharina M. HUSTER, Martina ŠIŠÁKOVÁ et. al.Basic information
Original name
Physiologic heart rate dependency of the PQ interval and its sex differences
Authors
TOMAN, Ondřej (203 Czech Republic, belonging to the institution), Kateřina HNÁTKOVÁ (203 Czech Republic), Peter SMETANA (620 Portugal), Katharina M. HUSTER (276 Germany), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Petra BARTHEL (276 Germany), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Georg SCHMIDT (276 Germany) and Marek MALÍK (203 Czech Republic, guarantor)
Edition
Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.379
RIV identification code
RIV/00216224:14110/20:00116357
Organization unit
Faculty of Medicine
UT WoS
000562888500027
Keywords in English
physiologic heart rate dependency; PQ interval; sex differences
Tags
International impact, Reviewed
Změněno: 10/9/2020 09:11, Mgr. Tereza Miškechová
Abstract
V originále
On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 +/- 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 +/- 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 +/- 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 +/- 81.1 vs 65.4 +/- 64.3 seconds, respectively, p < 0.00001). P wave duration was even less rate dependent than the PQ interval (9 +/- 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 +/- 8.4 vs 110.2 +/- 7.9 ms, p < 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.