Detailed Information on Publication Record
2021
Metabolic and Amino Acid Alterations of the Tumor Microenvironment
ŠTĚPKA, Petr, Vít VŠIANSKÝ, Martina RAUDENSKÁ, Jaromír GUMULEC, Adam VOJTĚCH et. al.Basic information
Original name
Metabolic and Amino Acid Alterations of the Tumor Microenvironment
Authors
ŠTĚPKA, Petr (203 Czech Republic, belonging to the institution), Vít VŠIANSKÝ (203 Czech Republic, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Adam VOJTĚCH (203 Czech Republic) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)
Edition
Current Medicinal Chemistry, Sharjah, BENTHAM SCIENCE PUBL LTD, 2021, 0929-8673
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
United Arab Emirates
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.740
RIV identification code
RIV/00216224:14110/21:00118758
Organization unit
Faculty of Medicine
UT WoS
000640182300001
Keywords in English
cancer metabolism; aspartate; glutamine; metastasis; methionine; sarcosine
Tags
International impact, Reviewed
Změněno: 2/6/2021 13:50, Mgr. Tereza Miškechová
Abstract
V originále
Metabolic changes driven by the hostile tumor microenvironment surrounding cancer cells and effect of these changes on tumorigenesis and metastatic potential have been known for a long time. The usual point of interest is glucose and changes in its utilization by cancer cells, mainly in the form of the Warburg effect. However, amino acids, both intra- and extracellular, also represent an important aspect of tumour microenvironment, which can have a significant effect on cancer cell metabolism and overall development of the tumor. Namely alterations in metabolism of amino acids glutamine, sarcosine, aspartate, methionine and cysteine have been previously connected to the tumor progression and aggressivity of prostate cancer. The aim of this review is to pinpoint current gaps in our knowledge of the role of amino acids as a part of the tumor microenvironment and to show effect of various amino acids on cancer cell metabolism and metastatic potential. This review shows limitations and exceptions from the traditionally accepted model of Warburg effect in some cancer tissues, with the emphasis on prostate cancer, because the traditional definition of Warburg effect as a metabolic switch to aerobic glycolysis does not always apply. Prostatic tissue both in healthy and transformed state significantly differs in many metabolic aspects, including the metabolisms of glucose and amino acids, from metabolism of other tissues. Findings from different tissues are therefore not always interchangeable and have to be taken into account during experimentation modifying the environment of tumor tissue by amino acid supplementation or depletion, which could potentially serve as a new therapeutic approach.
Links
| GA18-24089S, research and development project |
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| LQ1601, research and development project |
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| MUNI/A/1255/2018, interní kód MU |
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| MUNI/A/1453/2019, interní kód MU |
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| MUNI/A/1553/2018, interní kód MU |
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| ROZV/23/LF16/2019, interní kód MU |
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