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@article{1677817,
author = {Štěpka, Petr and Všianský, Vít and Raudenská, Martina and Gumulec, Jaromír and Vojtěch, Adam and Masařík, Michal},
article_location = {Sharjah},
article_number = {7},
doi = {http://dx.doi.org/10.2174/0929867327666200207114658},
keywords = {cancer metabolism; aspartate; glutamine; metastasis; methionine; sarcosine},
language = {eng},
issn = {0929-8673},
journal = {Current Medicinal Chemistry},
title = {Metabolic and Amino Acid Alterations of the Tumor Microenvironment},
url = {https://www.eurekaselect.com/179121/article},
volume = {28},
year = {2021}
}
TY - JOUR
ID - 1677817
AU - Štěpka, Petr - Všianský, Vít - Raudenská, Martina - Gumulec, Jaromír - Vojtěch, Adam - Masařík, Michal
PY - 2021
TI - Metabolic and Amino Acid Alterations of the Tumor Microenvironment
JF - Current Medicinal Chemistry
VL - 28
IS - 7
SP - 1270-1289
EP - 1270-1289
PB - BENTHAM SCIENCE PUBL LTD
SN - 09298673
KW - cancer metabolism
KW - aspartate
KW - glutamine
KW - metastasis
KW - methionine
KW - sarcosine
UR - https://www.eurekaselect.com/179121/article
L2 - https://www.eurekaselect.com/179121/article
N2 - Metabolic changes driven by the hostile tumor microenvironment surrounding cancer cells and effect of these changes on tumorigenesis and metastatic potential have been known for a long time. The usual point of interest is glucose and changes in its utilization by cancer cells, mainly in the form of the Warburg effect. However, amino acids, both intra- and extracellular, also represent an important aspect of tumour microenvironment, which can have a significant effect on cancer cell metabolism and overall development of the tumor. Namely alterations in metabolism of amino acids glutamine, sarcosine, aspartate, methionine and cysteine have been previously connected to the tumor progression and aggressivity of prostate cancer. The aim of this review is to pinpoint current gaps in our knowledge of the role of amino acids as a part of the tumor microenvironment and to show effect of various amino acids on cancer cell metabolism and metastatic potential. This review shows limitations and exceptions from the traditionally accepted model of Warburg effect in some cancer tissues, with the emphasis on prostate cancer, because the traditional definition of Warburg effect as a metabolic switch to aerobic glycolysis does not always apply. Prostatic tissue both in healthy and transformed state significantly differs in many metabolic aspects, including the metabolisms of glucose and amino acids, from metabolism of other tissues. Findings from different tissues are therefore not always interchangeable and have to be taken into account during experimentation modifying the environment of tumor tissue by amino acid supplementation or depletion, which could potentially serve as a new therapeutic approach.
ER -
ŠTĚPKA, Petr, Vít VŠIANSKÝ, Martina RAUDENSKÁ, Jaromír GUMULEC, Adam VOJTĚCH and Michal MASAŘÍK. Metabolic and Amino Acid Alterations of the Tumor Microenvironment. \textit{Current Medicinal Chemistry}. Sharjah: BENTHAM SCIENCE PUBL LTD, 2021, vol.~28, No~7, p.~1270-1289. ISSN~0929-8673. Available from: https://dx.doi.org/10.2174/0929867327666200207114658.
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