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@article{1677824,
author = {Fojtů, Michaela and Balvan, Jan and Raudenská, Martina and Vičar, Tomáš and Šturala, Jiří and Sofer, Zdeněk and Luxa, Jan and Plutnar, Jan and Masařík, Michal and Pumera, Martin},
article_location = {Amsterdam},
article_number = {SEP 2020},
doi = {http://dx.doi.org/10.1016/j.apmt.2020.100697},
keywords = {2D materials; 4-carboxybutylgermanane; germanane; targeted drug delivery; doxorubicin; ovarian cancer; drug resistance},
language = {eng},
issn = {2352-9407},
journal = {Applied Materials Today},
title = {2D Germanane Derivative as a Vector for Overcoming Doxorubicin Resistance in Cancer Cells},
url = {https://www.sciencedirect.com/science/article/pii/S235294072030144X},
volume = {20},
year = {2020}
}
TY - JOUR
ID - 1677824
AU - Fojtů, Michaela - Balvan, Jan - Raudenská, Martina - Vičar, Tomáš - Šturala, Jiří - Sofer, Zdeněk - Luxa, Jan - Plutnar, Jan - Masařík, Michal - Pumera, Martin
PY - 2020
TI - 2D Germanane Derivative as a Vector for Overcoming Doxorubicin Resistance in Cancer Cells
JF - Applied Materials Today
VL - 20
IS - SEP 2020
SP - 1-14
EP - 1-14
PB - Elsevier
SN - 23529407
KW - 2D materials
KW - 4-carboxybutylgermanane
KW - germanane
KW - targeted drug delivery
KW - doxorubicin
KW - ovarian cancer
KW - drug resistance
UR - https://www.sciencedirect.com/science/article/pii/S235294072030144X
L2 - https://www.sciencedirect.com/science/article/pii/S235294072030144X
N2 - Cancer resistance to chemotherapeutics is a common problem often encountered in the clinical setting, hampering greatly the conventional therapy of malignant diseases for several decades. No generally efficient mechanism solving this phenomenon was found so far. Cancer cells can adapt to a stress applied in the form of chemotherapeutics and become insensitive to their effects. Under such a selection pressure, the cancer cells acquire features helping them not only to survive the changes in the environment but also to further divide and to form secondary lesions. Therefore, besides developing novel chemotherapeutics, refining the drug delivery mechanisms of the conventional ones is absolutely crucial to defeat the cancer, so we can fully benefit from the effects these therapeutics offer. Here, we demonstrated enhanced delivery of doxorubicin (DOX) to a DOX-resistant ovarian cancer cell line using completely novel 2D material 4-carboxybutylgermanane (Ge-Bu-COOH). In our study, we present Ge-Bu-COOH as a drug carrier evincing high drug-loading efficiency, low cytotoxicity up to the concentration of 2.5 mu g/mL and no hemolysis. Simultaneously, binding DOX to Ge-Bu-COOH increases DOX accumulation in the DOXresistant cell lines. It leads to a significant anticancer efficiency enhancement in A2780/ADR DOX-resistant cell line; with the maximal effect reaching up to 62.8% compared to free DOX. These findings have profound influence on understanding the behaviour of doxorubicin-resistant tumours and open new horizon to manage their treatment. (c) 2020 Elsevier Ltd. All rights reserved.
ER -
FOJTŮ, Michaela, Jan BALVAN, Martina RAUDENSKÁ, Tomáš VIČAR, Jiří ŠTURALA, Zdeněk SOFER, Jan LUXA, Jan PLUTNAR, Michal MASAŘÍK and Martin PUMERA. 2D Germanane Derivative as a Vector for Overcoming Doxorubicin Resistance in Cancer Cells. \textit{Applied Materials Today}. Amsterdam: Elsevier, 2020, vol.~20, SEP 2020, p.~1-14. ISSN~2352-9407. Available from: https://dx.doi.org/10.1016/j.apmt.2020.100697.
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