Cerebrocerebellar structural covariance in temporal lobe
epilepsy with hippocampal sclerosis

J 2020

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

MARCIÁN, Václav, Radek MAREČEK, Martin PAIL and Milan BRÁZDIL

Basic information

Original name

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Authors

MARCIÁN, Václav (703 Slovakia, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Martin PAIL (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)

Edition

Epilepsy & Behavior, San Diego, Elsevier, 2020, 1525-5050

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.937

RIV identification code

RIV/00216224:14110/20:00116365

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.yebeh.2020.107180

UT WoS

000577327900017

Keywords in English

Temporal lobe epilepsy; Hippocampal sclerosis; Cerebellum; Structural covariance; Amygdala enlargement; Voxel-based morphometry

Abstract

V originále

Purpose The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermis and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLE-HS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

MARCIÁN, Václav, Radek MAREČEK, Martin PAIL and Milan BRÁZDIL. Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis. Epilepsy & Behavior. San Diego: Elsevier, 2020, vol. 111, OCT 2020, p. 1-8. ISSN 1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2020.107180.

@article{1677830,
   author = {Marcián, Václav and Mareček, Radek and Pail, Martin and Brázdil, Milan},
   article_location = {San Diego},
   article_number = {OCT 2020},
   doi = {http://dx.doi.org/10.1016/j.yebeh.2020.107180},
   keywords = {Temporal lobe epilepsy; Hippocampal sclerosis; Cerebellum; Structural covariance; Amygdala enlargement; Voxel-based morphometry},
   language = {eng},
   issn = {1525-5050},
   journal = {Epilepsy & Behavior},
   title = {Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis},
   url = {https://www.sciencedirect.com/science/article/pii/S1525505020303590},
   volume = {111},
   year = {2020}
}

TY  - JOUR
ID  - 1677830
AU  - Marcián, Václav - Mareček, Radek - Pail, Martin - Brázdil, Milan
PY  - 2020
TI  - Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis
JF  - Epilepsy & Behavior
VL  - 111
IS  - OCT 2020
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 15255050
KW  - Temporal lobe epilepsy
KW  - Hippocampal sclerosis
KW  - Cerebellum
KW  - Structural covariance
KW  - Amygdala enlargement
KW  - Voxel-based morphometry
UR  - https://www.sciencedirect.com/science/article/pii/S1525505020303590
L2  - https://www.sciencedirect.com/science/article/pii/S1525505020303590
N2  - Purpose The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermis and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLE-HS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus.
ER  -

MARCIÁN, Václav, Radek MAREČEK, Martin PAIL and Milan BRÁZDIL. Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis. \textit{Epilepsy \&{} Behavior}. San Diego: Elsevier, 2020, vol.~111, OCT 2020, p.~1-8. ISSN~1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2020.107180.

Detailed Information on Publication Record