The Effect of Mindfulness-Based Stress Reduction (MBSR) on
Depression, Cognition, and Immunity in Mild Cognitive
Impairment : A Pilot Feasibility Study

J 2020

The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study

MARCINIAK, Rafał, Rastislav ŠUMEC, Martin VYHNÁLEK, Kamila BENDÍČKOVÁ, Petra LÁZNIČKOVÁ et. al.

Basic information

Original name

The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study

Authors

MARCINIAK, Rafał (203 Czech Republic, belonging to the institution), Rastislav ŠUMEC (703 Slovakia, belonging to the institution), Martin VYHNÁLEK (203 Czech Republic), Kamila BENDÍČKOVÁ (203 Czech Republic), Petra LÁZNIČKOVÁ (203 Czech Republic, belonging to the institution), Giancarlo FORTE (380 Italy), Andrej JELENÍK (203 Czech Republic), Veronika ŘÍMALOVÁ (203 Czech Republic), Jan FRIČ (203 Czech Republic), Jakub HORT (203 Czech Republic) and Kateřina SHEARDOVÁ (203 Czech Republic, guarantor)

Edition

Clinical Interventions in Aging, Auckland, DOVE MEDICAL PRESS, 2020, 1176-9092

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30227 Geriatrics and gerontology

Country of publisher

New Zealand

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.824 in 2013

RIV identification code

RIV/00216224:14110/20:00116380

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2147/CIA.S249196

UT WoS

000575553400001

Keywords in English

cognition; depression; anxiety; MCI; neurodegeneration; monocyte activation

Abstract

V originále

Background: Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups. Objective: To determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training. Methods: Twenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2. Results: Twenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition - a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT=36) was associated with the lower adherence to home practice. Conclusion: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile. Keywords

Links

MUNI/A/1204/2017, interní kód MU

Name: Matematické statistické modelování 2 (Acronym: MaStaMo2)

Investor: Masaryk University, Category A

Citovat

MARCINIAK, Rafał, Rastislav ŠUMEC, Martin VYHNÁLEK, Kamila BENDÍČKOVÁ, Petra LÁZNIČKOVÁ, Giancarlo FORTE, Andrej JELENÍK, Veronika ŘÍMALOVÁ, Jan FRIČ, Jakub HORT and Kateřina SHEARDOVÁ. The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study. Clinical Interventions in Aging. Auckland: DOVE MEDICAL PRESS, 2020, vol. 15, August, p. 1365-1381. ISSN 1176-9092. Available from: https://dx.doi.org/10.2147/CIA.S249196.

@article{1678016,
   author = {Marciniak, Rafał and Šumec, Rastislav and Vyhnálek, Martin and Bendíčková, Kamila and Lázničková, Petra and Forte, Giancarlo and Jeleník, Andrej and Římalová, Veronika and Frič, Jan and Hort, Jakub and Sheardová, Kateřina},
   article_location = {Auckland},
   article_number = {August},
   doi = {http://dx.doi.org/10.2147/CIA.S249196},
   keywords = {cognition; depression; anxiety; MCI; neurodegeneration; monocyte activation},
   language = {eng},
   issn = {1176-9092},
   journal = {Clinical Interventions in Aging},
   title = {The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study},
   url = {https://www.dovepress.com/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-co-peer-reviewed-article-CIA},
   volume = {15},
   year = {2020}
}

TY  - JOUR
ID  - 1678016
AU  - Marciniak, Rafał - Šumec, Rastislav - Vyhnálek, Martin - Bendíčková, Kamila - Lázničková, Petra - Forte, Giancarlo - Jeleník, Andrej - Římalová, Veronika - Frič, Jan - Hort, Jakub - Sheardová, Kateřina
PY  - 2020
TI  - The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study
JF  - Clinical Interventions in Aging
VL  - 15
IS  - August
SP  - 1365-1381
EP  - 1365-1381
PB  - DOVE MEDICAL PRESS
SN  - 11769092
KW  - cognition
KW  - depression
KW  - anxiety
KW  - MCI
KW  - neurodegeneration
KW  - monocyte activation
UR  - https://www.dovepress.com/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-co-peer-reviewed-article-CIA
L2  - https://www.dovepress.com/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-co-peer-reviewed-article-CIA
N2  - Background: Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups. Objective: To determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training. Methods: Twenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2. Results: Twenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition - a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT=36) was associated with the lower adherence to home practice. Conclusion: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile. Keywords
ER  -

MARCINIAK, Rafał, Rastislav ŠUMEC, Martin VYHNÁLEK, Kamila BENDÍČKOVÁ, Petra LÁZNIČKOVÁ, Giancarlo FORTE, Andrej JELENÍK, Veronika ŘÍMALOVÁ, Jan FRIČ, Jakub HORT and Kateřina SHEARDOVÁ. The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study. \textit{Clinical Interventions in Aging}. Auckland: DOVE MEDICAL PRESS, 2020, vol.~15, August, p.~1365-1381. ISSN~1176-9092. Available from: https://dx.doi.org/10.2147/CIA.S249196.

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