Delayed-type Hypersensitivity to Metals in Newly Diagnosed
Patients with Nonischemic Dilated Cardiomyopathy

J 2020

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy

MAŇOUSEK, Jan, Marián FELŠŐCI, Roman MIKLÍK, Jiří PAŘENICA, Jan KREJČÍ et. al.

Basic information

Original name

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy

Authors

MAŇOUSEK, Jan (203 Czech Republic), Marián FELŠŐCI (703 Slovakia, belonging to the institution), Roman MIKLÍK (203 Czech Republic, guarantor), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Geir BJORKLUND (578 Norway), Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution), Dalibor MLEJNEK (203 Czech Republic, belonging to the institution), Marie MIKLÍKOVÁ (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic, belonging to the institution), Salvatore CHIRUMBOLO (380 Italy) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution)

Edition

Cardiovascular Toxicology, Totowa, Humana Press, 2020, 1530-7905

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.231

RIV identification code

RIV/00216224:14110/20:00116415

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12012-020-09582-6

UT WoS

000540967000001

Keywords in English

Dilated cardiomyopathy; Metal exposure; Delayed-type hypersensitivity; Lymphocyte transformation test; Inflammation

Abstract

V originále

The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA (R)) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (p = 0.0002), aluminum (p = 0.0006), nickel (p = 0.0012), and chromium (p = 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,p = 0.014624), nickel (40% vs. 12.2%,p = 0.02341), and silver (20% vs. 4.8%,p = 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

Citovat

MAŇOUSEK, Jan, Marián FELŠŐCI, Roman MIKLÍK, Jiří PAŘENICA, Jan KREJČÍ, Geir BJORKLUND, Jana KLÁNOVÁ, Dalibor MLEJNEK, Marie MIKLÍKOVÁ, Petr LOKAJ, Salvatore CHIRUMBOLO and Jindřich ŠPINAR. Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy. Cardiovascular Toxicology. Totowa: Humana Press, 2020, vol. 20, No 6, p. 571-580. ISSN 1530-7905. Available from: https://dx.doi.org/10.1007/s12012-020-09582-6.

@article{1678923,
   author = {Maňousek, Jan and Felšőci, Marián and Miklík, Roman and Pařenica, Jiří and Krejčí, Jan and Bjorklund, Geir and Klánová, Jana and Mlejnek, Dalibor and Miklíková, Marie and Lokaj, Petr and Chirumbolo, Salvatore and Špinar, Jindřich},
   article_location = {Totowa},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s12012-020-09582-6},
   keywords = {Dilated cardiomyopathy; Metal exposure; Delayed-type hypersensitivity; Lymphocyte transformation test; Inflammation},
   language = {eng},
   issn = {1530-7905},
   journal = {Cardiovascular Toxicology},
   note = {CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.},
   title = {Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy},
   url = {https://link.springer.com/article/10.1007%2Fs12012-020-09582-6},
   volume = {20},
   year = {2020}
}

TY  - JOUR
ID  - 1678923
AU  - Maňousek, Jan - Felšőci, Marián - Miklík, Roman - Pařenica, Jiří - Krejčí, Jan - Bjorklund, Geir - Klánová, Jana - Mlejnek, Dalibor - Miklíková, Marie - Lokaj, Petr - Chirumbolo, Salvatore - Špinar, Jindřich
PY  - 2020
TI  - Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy
JF  - Cardiovascular Toxicology
VL  - 20
IS  - 6
SP  - 571-580
EP  - 571-580
PB  - Humana Press
SN  - 15307905
N1  - CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.
KW  - Dilated cardiomyopathy
KW  - Metal exposure
KW  - Delayed-type hypersensitivity
KW  - Lymphocyte transformation test
KW  - Inflammation
UR  - https://link.springer.com/article/10.1007%2Fs12012-020-09582-6
L2  - https://link.springer.com/article/10.1007%2Fs12012-020-09582-6
N2  - The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA (R)) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (p = 0.0002), aluminum (p = 0.0006), nickel (p = 0.0012), and chromium (p = 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,p = 0.014624), nickel (40% vs. 12.2%,p = 0.02341), and silver (20% vs. 4.8%,p = 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation.
ER  -

MAŇOUSEK, Jan, Marián FELŠ$\backslash$H OCI, Roman MIKLÍK, Jiří PAŘENICA, Jan KREJČÍ, Geir BJORKLUND, Jana KLÁNOVÁ, Dalibor MLEJNEK, Marie MIKLÍKOVÁ, Petr LOKAJ, Salvatore CHIRUMBOLO and Jindřich ŠPINAR. Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy. \textit{Cardiovascular Toxicology}. Totowa: Humana Press, 2020, vol.~20, No~6, p.~571-580. ISSN~1530-7905. Available from: https://dx.doi.org/10.1007/s12012-020-09582-6.

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