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@article{1678923,
author = {Maňousek, Jan and Felšőci, Marián and Miklík, Roman and Pařenica, Jiří and Krejčí, Jan and Bjorklund, Geir and Klánová, Jana and Mlejnek, Dalibor and Miklíková, Marie and Lokaj, Petr and Chirumbolo, Salvatore and Špinar, Jindřich},
article_location = {Totowa},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s12012-020-09582-6},
keywords = {Dilated cardiomyopathy; Metal exposure; Delayed-type hypersensitivity; Lymphocyte transformation test; Inflammation},
language = {eng},
issn = {1530-7905},
journal = {Cardiovascular Toxicology},
note = {CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.},
title = {Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy},
url = {https://link.springer.com/article/10.1007%2Fs12012-020-09582-6},
volume = {20},
year = {2020}
}
TY - JOUR
ID - 1678923
AU - Maňousek, Jan - Felšőci, Marián - Miklík, Roman - Pařenica, Jiří - Krejčí, Jan - Bjorklund, Geir - Klánová, Jana - Mlejnek, Dalibor - Miklíková, Marie - Lokaj, Petr - Chirumbolo, Salvatore - Špinar, Jindřich
PY - 2020
TI - Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy
JF - Cardiovascular Toxicology
VL - 20
IS - 6
SP - 571-580
EP - 571-580
PB - Humana Press
SN - 15307905
N1 - CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.
KW - Dilated cardiomyopathy
KW - Metal exposure
KW - Delayed-type hypersensitivity
KW - Lymphocyte transformation test
KW - Inflammation
UR - https://link.springer.com/article/10.1007%2Fs12012-020-09582-6
L2 - https://link.springer.com/article/10.1007%2Fs12012-020-09582-6
N2 - The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA (R)) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (p = 0.0002), aluminum (p = 0.0006), nickel (p = 0.0012), and chromium (p = 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,p = 0.014624), nickel (40% vs. 12.2%,p = 0.02341), and silver (20% vs. 4.8%,p = 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation.
ER -
MAŇOUSEK, Jan, Marián FELŠ$\backslash$H OCI, Roman MIKLÍK, Jiří PAŘENICA, Jan KREJČÍ, Geir BJORKLUND, Jana KLÁNOVÁ, Dalibor MLEJNEK, Marie MIKLÍKOVÁ, Petr LOKAJ, Salvatore CHIRUMBOLO and Jindřich ŠPINAR. Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy. \textit{Cardiovascular Toxicology}. Totowa: Humana Press, 2020, vol.~20, No~6, p.~571-580. ISSN~1530-7905. Available from: https://dx.doi.org/10.1007/s12012-020-09582-6.
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