| MAZUMDAR, Aninda, Yazan HADDAD, Vishma Pratap SUR, Vedran MILOSAVLJEVIC, Sukanya BHOWMICK, Hana MICHÁLKOVÁ, Roman GURÁŇ, Radek VESELÝ and Amitava MOULICK. Characterization and in vitro Analysis of Probiotic-Derived Peptides Against Multi Drug Resistance Bacterial Infections. Frontiers in Microbiology. Lausanne: Frontiers Media SA, 2020, vol. 11, August 2020, p. 1-19. ISSN 1664-302X. Available from: https://dx.doi.org/10.3389/fmicb.2020.01963. |
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@article{1679398,
author = {Mazumdar, Aninda and Haddad, Yazan and Sur, Vishma Pratap and Milosavljevic, Vedran and Bhowmick, Sukanya and Michálková, Hana and Guráň, Roman and Veselý, Radek and Moulick, Amitava},
article_location = {Lausanne},
article_number = {August 2020},
doi = {http://dx.doi.org/10.3389/fmicb.2020.01963},
keywords = {antibacterial peptides antibiotics multidrug resistance bacteria infections},
language = {eng},
issn = {1664-302X},
journal = {Frontiers in Microbiology},
title = {Characterization and in vitro Analysis of Probiotic-Derived Peptides Against Multi Drug Resistance Bacterial Infections},
url = {https://www.frontiersin.org/articles/10.3389/fmicb.2020.01963/full},
volume = {11},
year = {2020}
}
TY - JOUR
ID - 1679398
AU - Mazumdar, Aninda - Haddad, Yazan - Sur, Vishma Pratap - Milosavljevic, Vedran - Bhowmick, Sukanya - Michálková, Hana - Guráň, Roman - Veselý, Radek - Moulick, Amitava
PY - 2020
TI - Characterization and in vitro Analysis of Probiotic-Derived Peptides Against Multi Drug Resistance Bacterial Infections
JF - Frontiers in Microbiology
VL - 11
IS - August 2020
SP - 1-19
EP - 1-19
PB - Frontiers Media SA
SN - 1664302X
KW - antibacterial peptides antibiotics multidrug resistance bacteria infections
UR - https://www.frontiersin.org/articles/10.3389/fmicb.2020.01963/full
L2 - https://www.frontiersin.org/articles/10.3389/fmicb.2020.01963/full
N2 - An inexorable switch from antibiotics has become a major desideratum to overcome antibiotic resistance. Bacteriocin fromLactobacillus casei, a cardinal probiotic was used to design novel antibacterial peptides named as Probiotic Bacteriocin Derived and Modified (PBDM) peptides (PBDM1: YKWFAHLIKGLC and PBDM2: YKWFRHLIKKLC). The loop-shaped 3D structure of peptides was characterizedin silicovia molecular dynamics simulation as well as biophysically via spectroscopic methods. Thereafter,in vitroresults against multidrug resistant bacterial strains and hospital samples demonstrated the strong antimicrobial activity of PBDM peptides. Further,in vivostudies with PBDM peptides showed downright recovery of balb/c mice from Vancomycin ResistantStaphylococcus aureus(VRSA) infection to its healthy condition. Thereafter,in vitrostudy with human epithelial cells showed no significant cytotoxic effects with high biocompatibility and good hemocompatibility. In conclusion, PBDM peptides displayed significant antibacterial activity against certain drug resistant bacteria which cause infections in human beings. Future analysis are required to unveil its mechanism of action in order to execute it as an alternative to antibiotics.
ER -
MAZUMDAR, Aninda, Yazan HADDAD, Vishma Pratap SUR, Vedran MILOSAVLJEVIC, Sukanya BHOWMICK, Hana MICHÁLKOVÁ, Roman GURÁŇ, Radek VESELÝ and Amitava MOULICK. Characterization and in vitro Analysis of Probiotic-Derived Peptides Against Multi Drug Resistance Bacterial Infections. \textit{Frontiers in Microbiology}. Lausanne: Frontiers Media SA, 2020, vol.~11, August 2020, p.~1-19. ISSN~1664-302X. Available from: https://dx.doi.org/10.3389/fmicb.2020.01963.
|
