| NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ and Zdeněk GLATZ. Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin. Journa of Separation Science. Weinheim: Wiley-VCH, 2020, vol. 43, No 22, p. 4225-4233. ISSN 1615-9306. Available from: https://dx.doi.org/10.1002/jssc.202000594. |
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@article{1679993,
author = {Nevídalová, Hana and Michalcová, Lenka and Glatz, Zdeněk},
article_location = {Weinheim},
article_number = {22},
doi = {http://dx.doi.org/10.1002/jssc.202000594},
keywords = {CE; Albumin; Drug},
language = {eng},
issn = {1615-9306},
journal = {Journa of Separation Science},
title = {Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin},
url = {https://doi.org/10.1002/jssc.202000594},
volume = {43},
year = {2020}
}
TY - JOUR
ID - 1679993
AU - Nevídalová, Hana - Michalcová, Lenka - Glatz, Zdeněk
PY - 2020
TI - Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin
JF - Journa of Separation Science
VL - 43
IS - 22
SP - 4225-4233
EP - 4225-4233
PB - Wiley-VCH
SN - 16159306
KW - CE
KW - Albumin
KW - Drug
UR - https://doi.org/10.1002/jssc.202000594
L2 - https://doi.org/10.1002/jssc.202000594
N2 - In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal analysis, and the obtained values of binding parameters were compared with the literature data. The affect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.
ER -
NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ and Zdeněk GLATZ. Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin. \textit{Journa of Separation Science}. Weinheim: Wiley-VCH, 2020, vol.~43, No~22, p.~4225-4233. ISSN~1615-9306. Available from: https://dx.doi.org/10.1002/jssc.202000594.
|
