Dietary Intake of Acrylamide and Risk of Breast, Endometrial,
and Ovarian Cancers: A Systematic Review and Dose-Response
Meta-analysis

J 2020

Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis

ADANI, Giorgia, Tommaso FILIPPINI, Lauren A. WISE, Thorhallur I. HALLDORSSON, Luděk BLÁHA et. al.

Basic information

Original name

Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis

Authors

ADANI, Giorgia (380 Italy), Tommaso FILIPPINI (380 Italy), Lauren A. WISE (840 United States of America), Thorhallur I. HALLDORSSON (208 Denmark), Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution) and Marco VINCETI (380 Italy)

Edition

Cancer Epidemiology, Biomarkers & Prevention, Philadelphia, American Association for Cancer Research, 2020, 1055-9965

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.254

RIV identification code

RIV/00216224:14310/20:00116472

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1158/1055-9965.EPI-19-1628

UT WoS

000539997800002

Keywords in English

NONSMOKING POSTMENOPAUSAL WOMEN; HEMOGLOBIN ADDUCT LEVELS; PROSPECTIVE COHORT; DRINKING-WATER; B6C3F(1) MICE; AIR-POLLUTION; F344/N RATS; GLYCIDAMIDE; EXPOSURE; CARCINOGENICITY

Abstract

V originále

Acrylamide is a probable human carcinogen. Aside from occupational exposures and smoking, diet is the main source of exposure in humans. We performed a systematic review of the association between estimated dietary intake of acrylamide and risk of female breast, endometrial, and ovarian cancers in nonexperimental studies published through February 25, 2020, and conducted a dose-response meta-analysis. We identified 18 papers covering 10 different study populations: 16 cohort and two case-control studies. Acrylamide intake was associated with a slightly increased risk of ovarian cancer, particularly among never smokers. For endometrial cancer, risk was highest at intermediate levels of exposure, whereas the association was more linear and positive among never smokers. For breast cancer, we found evidence of a null or inverse relation between exposure and risk, particularly among never smokers and postmenopausal women. In a subgroup analysis limited to premenopausal women, breast cancer risk increased linearly with acrylamide intake starting at 20 mg/day of intake. High acrylamide intake was associated with increased risks of ovarian and endometrial cancers in a relatively linear manner, especially among never smokers. Conversely, little association was observed between acrylamide intake and breast cancer risk, with the exception of premenopausal women.

Links

733032, interní kód MU

Name: European Human Biomonitoring Initiative (Acronym: HBM4EU)

Investor: European Union, Health, demographic change and wellbeing (Societal Challenges)

Citovat

ADANI, Giorgia, Tommaso FILIPPINI, Lauren A. WISE, Thorhallur I. HALLDORSSON, Luděk BLÁHA and Marco VINCETI. Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis. Cancer Epidemiology, Biomarkers & Prevention. Philadelphia: American Association for Cancer Research, 2020, vol. 29, No 6, p. 1095-1106. ISSN 1055-9965. Available from: https://dx.doi.org/10.1158/1055-9965.EPI-19-1628.

@article{1680257,
   author = {Adani, Giorgia and Filippini, Tommaso and Wise, Lauren A. and Halldorsson, Thorhallur I. and Bláha, Luděk and Vinceti, Marco},
   article_location = {Philadelphia},
   article_number = {6},
   doi = {http://dx.doi.org/10.1158/1055-9965.EPI-19-1628},
   keywords = {NONSMOKING POSTMENOPAUSAL WOMEN; HEMOGLOBIN ADDUCT LEVELS; PROSPECTIVE COHORT; DRINKING-WATER; B6C3F(1) MICE; AIR-POLLUTION; F344/N RATS; GLYCIDAMIDE; EXPOSURE; CARCINOGENICITY},
   language = {eng},
   issn = {1055-9965},
   journal = {Cancer Epidemiology, Biomarkers & Prevention},
   title = {Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis},
   url = {https://cebp.aacrjournals.org/content/29/6/1095},
   volume = {29},
   year = {2020}
}

TY  - JOUR
ID  - 1680257
AU  - Adani, Giorgia - Filippini, Tommaso - Wise, Lauren A. - Halldorsson, Thorhallur I. - Bláha, Luděk - Vinceti, Marco
PY  - 2020
TI  - Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis
JF  - Cancer Epidemiology, Biomarkers & Prevention
VL  - 29
IS  - 6
SP  - 1095-1106
EP  - 1095-1106
PB  - American Association for Cancer Research
SN  - 10559965
KW  - NONSMOKING POSTMENOPAUSAL WOMEN
KW  - HEMOGLOBIN ADDUCT LEVELS
KW  - PROSPECTIVE COHORT
KW  - DRINKING-WATER
KW  - B6C3F(1) MICE
KW  - AIR-POLLUTION
KW  - F344/N RATS
KW  - GLYCIDAMIDE
KW  - EXPOSURE
KW  - CARCINOGENICITY
UR  - https://cebp.aacrjournals.org/content/29/6/1095
L2  - https://cebp.aacrjournals.org/content/29/6/1095
N2  - Acrylamide is a probable human carcinogen. Aside from occupational exposures and smoking, diet is the main source of exposure in humans. We performed a systematic review of the association between estimated dietary intake of acrylamide and risk of female breast, endometrial, and ovarian cancers in nonexperimental studies published through February 25, 2020, and conducted a dose-response meta-analysis. We identified 18 papers covering 10 different study populations: 16 cohort and two case-control studies. Acrylamide intake was associated with a slightly increased risk of ovarian cancer, particularly among never smokers. For endometrial cancer, risk was highest at intermediate levels of exposure, whereas the association was more linear and positive among never smokers. For breast cancer, we found evidence of a null or inverse relation between exposure and risk, particularly among never smokers and postmenopausal women. In a subgroup analysis limited to premenopausal women, breast cancer risk increased linearly with acrylamide intake starting at 20 mg/day of intake. High acrylamide intake was associated with increased risks of ovarian and endometrial cancers in a relatively linear manner, especially among never smokers. Conversely, little association was observed between acrylamide intake and breast cancer risk, with the exception of premenopausal women.
ER  -

ADANI, Giorgia, Tommaso FILIPPINI, Lauren A. WISE, Thorhallur I. HALLDORSSON, Luděk BLÁHA and Marco VINCETI. Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis. \textit{Cancer Epidemiology, Biomarkers \&{} Prevention}. Philadelphia: American Association for Cancer Research, 2020, vol.~29, No~6, p.~1095-1106. ISSN~1055-9965. Available from: https://dx.doi.org/10.1158/1055-9965.EPI-19-1628.

Detailed Information on Publication Record