| LISKOVA, Alena, Lenka KOKLESOVA, Marek SAMEC, Elizabeth VARGHESE, Mariam ABOTALEB, Samson Mathews SAMUEL, Karel ŠMEJKAL, Kamil BIRINGER, Martin PETRAS, Dana BLAHUTOVA, Ondrej BUGOS, Martin PEC, Marian ADAMKOV, Dietrich BUSSELBERG, Rachele CICCOCIOPPO, Mariusz ADAMEK, Luis RODRIGO, Martin CAPRNDA, Peter KRUŽLIAK and Peter KUBATKA. Implications of flavonoids as potential modulators of cancer neovascularity. Journal of cancer research and clinical oncology. Germany: Springer-Verlag, 2020, vol. 146, No 12, p. 3079-3096. ISSN 0171-5216. Available from: https://dx.doi.org/10.1007/s00432-020-03383-8. |
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@article{1680299,
author = {Liskova, Alena and Koklesova, Lenka and Samec, Marek and Varghese, Elizabeth and Abotaleb, Mariam and Samuel, Samson Mathews and Šmejkal, Karel and Biringer, Kamil and Petras, Martin and Blahutova, Dana and Bugos, Ondrej and Pec, Martin and Adamkov, Marian and Busselberg, Dietrich and Ciccocioppo, Rachele and Adamek, Mariusz and Rodrigo, Luis and Caprnda, Martin and Kružliak, Peter and Kubatka, Peter},
article_location = {Germany},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s00432-020-03383-8},
keywords = {Cancer; Tumor angiogenesis; Neovascularity; Flavonoids; VEGF; Anti-cancer therapy},
language = {eng},
issn = {0171-5216},
journal = {Journal of cancer research and clinical oncology},
title = {Implications of flavonoids as potential modulators of cancer neovascularity},
url = {https://link.springer.com/article/10.1007/s00432-020-03383-8},
volume = {146},
year = {2020}
}
TY - JOUR
ID - 1680299
AU - Liskova, Alena - Koklesova, Lenka - Samec, Marek - Varghese, Elizabeth - Abotaleb, Mariam - Samuel, Samson Mathews - Šmejkal, Karel - Biringer, Kamil - Petras, Martin - Blahutova, Dana - Bugos, Ondrej - Pec, Martin - Adamkov, Marian - Busselberg, Dietrich - Ciccocioppo, Rachele - Adamek, Mariusz - Rodrigo, Luis - Caprnda, Martin - Kružliak, Peter - Kubatka, Peter
PY - 2020
TI - Implications of flavonoids as potential modulators of cancer neovascularity
JF - Journal of cancer research and clinical oncology
VL - 146
IS - 12
SP - 3079-3096
EP - 3079-3096
PB - Springer-Verlag
SN - 01715216
KW - Cancer
KW - Tumor angiogenesis
KW - Neovascularity
KW - Flavonoids
KW - VEGF
KW - Anti-cancer therapy
UR - https://link.springer.com/article/10.1007/s00432-020-03383-8
L2 - https://link.springer.com/article/10.1007/s00432-020-03383-8
N2 - Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. Methods This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. Results and conclusion Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
ER -
LISKOVA, Alena, Lenka KOKLESOVA, Marek SAMEC, Elizabeth VARGHESE, Mariam ABOTALEB, Samson Mathews SAMUEL, Karel ŠMEJKAL, Kamil BIRINGER, Martin PETRAS, Dana BLAHUTOVA, Ondrej BUGOS, Martin PEC, Marian ADAMKOV, Dietrich BUSSELBERG, Rachele CICCOCIOPPO, Mariusz ADAMEK, Luis RODRIGO, Martin CAPRNDA, Peter KRUŽLIAK and Peter KUBATKA. Implications of flavonoids as potential modulators of cancer neovascularity. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2020, vol.~146, No~12, p.~3079-3096. ISSN~0171-5216. Available from: https://dx.doi.org/10.1007/s00432-020-03383-8.
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