Can oocytes repair fragmented DNA of spermatozoa?

J 2020

Can oocytes repair fragmented DNA of spermatozoa?

JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA et. al.

Basic information

Original name

Can oocytes repair fragmented DNA of spermatozoa?

Name in Czech

Mohou oocyty opravit fragmentovanou DNA spermií?

Authors

JEŠETA, Michal (203 Czech Republic, guarantor, belonging to the institution), Markéta MYŠKOVÁ (203 Czech Republic, belonging to the institution), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution), Igor CRHA (203 Czech Republic, belonging to the institution), Karel CRHA (203 Czech Republic, belonging to the institution), Eva CHMELÍKOVÁ (203 Czech Republic), Elena KISTANOVA (100 Bulgaria) and Pavel VENTRUBA (203 Czech Republic, belonging to the institution)

Edition

Medical Journal of Cell Biology, Walter de Gruyter, 2020, 2544-3577

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/20:00116518

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2478/acb-2020-0008

Keywords (in Czech)

spermie; integrita DNA; apoptóza; příprava spermií

Keywords in English

spermatozoa; DNA integrity; apoptosis; sperm preparation

Abstract

V originále

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes. © 2020 WDG. All rights reserved.

Citovat

JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA, Eva CHMELÍKOVÁ, Elena KISTANOVA and Pavel VENTRUBA. Can oocytes repair fragmented DNA of spermatozoa? Medical Journal of Cell Biology. Walter de Gruyter, 2020, vol. 8, No 2, p. 73-77. ISSN 2544-3577. Available from: https://dx.doi.org/10.2478/acb-2020-0008.

@article{1681577,
   author = {Ješeta, Michal and Myšková, Markéta and Žáková, Jana and Crha, Igor and Crha, Karel and Chmelíková, Eva and Kistanova, Elena and Ventruba, Pavel},
   article_number = {2},
   doi = {http://dx.doi.org/10.2478/acb-2020-0008},
   keywords = {spermatozoa; DNA integrity; apoptosis; sperm preparation},
   language = {eng},
   issn = {2544-3577},
   journal = {Medical Journal of Cell Biology},
   title = {Can oocytes repair fragmented DNA of spermatozoa?},
   url = {https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml},
   volume = {8},
   year = {2020}
}

TY  - JOUR
ID  - 1681577
AU  - Ješeta, Michal - Myšková, Markéta - Žáková, Jana - Crha, Igor - Crha, Karel - Chmelíková, Eva - Kistanova, Elena - Ventruba, Pavel
PY  - 2020
TI  - Can oocytes repair fragmented DNA of spermatozoa?
JF  - Medical Journal of Cell Biology
VL  - 8
IS  - 2
SP  - 73-77
EP  - 73-77
PB  - Walter de Gruyter
SN  - 25443577
KW  - spermatozoa
KW  - DNA integrity
KW  - apoptosis
KW  - sperm preparation
UR  - https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml
L2  - https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml
N2  - Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes. © 2020 WDG. All rights reserved.
ER  -

JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA, Eva CHMELÍKOVÁ, Elena KISTANOVA and Pavel VENTRUBA. Can oocytes repair fragmented DNA of spermatozoa? \textit{Medical Journal of Cell Biology}. Walter de Gruyter, 2020, vol.~8, No~2, p.~73-77. ISSN~2544-3577. Available from: https://dx.doi.org/10.2478/acb-2020-0008.

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