J 2020

Differences in monocyte subsets are associated with short-term survival in patients with septic shock

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ, Kamila BENDÍČKOVÁ, Marco De ZUANI, Ivana ANDREJČINOVÁ et. al.

Basic information

Original name

Differences in monocyte subsets are associated with short-term survival in patients with septic shock

Authors

HORTOVÁ KOHOUTKOVÁ, Marcela (203 Czech Republic), Petra LÁZNIČKOVÁ (203 Czech Republic, belonging to the institution), Kamila BENDÍČKOVÁ (203 Czech Republic), Marco De ZUANI, Ivana ANDREJČINOVÁ (703 Slovakia, belonging to the institution), Veronika TOMÁŠKOVÁ (203 Czech Republic, belonging to the institution), Pavel SUK (203 Czech Republic, belonging to the institution), Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution), Martin HELÁN (203 Czech Republic, belonging to the institution) and Jan FRIČ (203 Czech Republic, guarantor)

Edition

Journal of Cellular and Molecular Medicine, Hoboken, Wiley-Blackwell, 2020, 1582-1838

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.310

RIV identification code

RIV/00216224:14110/20:00116527

Organization unit

Faculty of Medicine

DOI

UT WoS

000570709800001

Keywords in English

cytokines; immunity; inflammation; monocytes; sepsis; septic shock; T cells

Tags

Tags

International impact, Reviewed
Změněno: 9/12/2020 08:11, Mgr. Tereza Miškechová

Abstract

V originále

Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic shock. Circulating monocytes and other innate immune cells are among the first ones to recognize and clear pathogens. Monocytes have an important role in sepsis and septic shock and have been studied as potential diagnostic markers. In total, forty-two patients with septic shock were recruited and blood samples obtained within first 12 hours of ICU admission. We showed that frequency of classical and intermediate monocytes assessed at the time of admission to the intensive care unit are significantly distinct in patients with septic shock who survived longer that five days from those who died. These parameters correlate significantly with differences in serum levels of inflammatory cytokines MCP-1, IL-6, IL-8, IL-10, and IL-18, and with the proportion of helper and cytotoxic T cells. The described changes in frequency of monocyte subsets and their activation status may predict short-term septic shock survival and help with fast identification of the group of vulnerable patients, who may profit from tailored therapy.