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@article{1681797,
author = {Hortová Kohoutková, Marcela and Lázničková, Petra and Bendíčková, Kamila and Zuani, Marco De and Andrejčinová, Ivana and Tomášková, Veronika and Suk, Pavel and Šrámek, Vladimír and Helán, Martin and Frič, Jan},
article_location = {Hoboken},
article_number = {21},
doi = {http://dx.doi.org/10.1111/jcmm.15791},
keywords = {cytokines; immunity; inflammation; monocytes; sepsis; septic shock; T cells},
language = {eng},
issn = {1582-1838},
journal = {Journal of Cellular and Molecular Medicine},
title = {Differences in monocyte subsets are associated with short-term survival in patients with septic shock},
url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15791},
volume = {24},
year = {2020}
}
TY - JOUR
ID - 1681797
AU - Hortová Kohoutková, Marcela - Lázničková, Petra - Bendíčková, Kamila - Zuani, Marco De - Andrejčinová, Ivana - Tomášková, Veronika - Suk, Pavel - Šrámek, Vladimír - Helán, Martin - Frič, Jan
PY - 2020
TI - Differences in monocyte subsets are associated with short-term survival in patients with septic shock
JF - Journal of Cellular and Molecular Medicine
VL - 24
IS - 21
SP - 12504-12512
EP - 12504-12512
PB - Wiley-Blackwell
SN - 15821838
KW - cytokines
KW - immunity
KW - inflammation
KW - monocytes
KW - sepsis
KW - septic shock
KW - T cells
UR - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15791
L2 - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15791
N2 - Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic shock. Circulating monocytes and other innate immune cells are among the first ones to recognize and clear pathogens. Monocytes have an important role in sepsis and septic shock and have been studied as potential diagnostic markers. In total, forty-two patients with septic shock were recruited and blood samples obtained within first 12 hours of ICU admission. We showed that frequency of classical and intermediate monocytes assessed at the time of admission to the intensive care unit are significantly distinct in patients with septic shock who survived longer that five days from those who died. These parameters correlate significantly with differences in serum levels of inflammatory cytokines MCP-1, IL-6, IL-8, IL-10, and IL-18, and with the proportion of helper and cytotoxic T cells. The described changes in frequency of monocyte subsets and their activation status may predict short-term septic shock survival and help with fast identification of the group of vulnerable patients, who may profit from tailored therapy.
ER -
HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ, Kamila BENDÍČKOVÁ, Marco De ZUANI, Ivana ANDREJČINOVÁ, Veronika TOMÁŠKOVÁ, Pavel SUK, Vladimír ŠRÁMEK, Martin HELÁN and Jan FRIČ. Differences in monocyte subsets are associated with short-term survival in patients with septic shock. \textit{Journal of Cellular and Molecular Medicine}. Hoboken: Wiley-Blackwell, 2020, vol.~24, No~21, p.~12504-12512. ISSN~1582-1838. Available from: https://dx.doi.org/10.1111/jcmm.15791.
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