HERMANS, C., P. L. F. GIANGRANDE, B. O MAHONY, P. DE KLEIJN, M. BEDFORD, A. BATOROVA, Jan BLATNÝ and K. JANSONE. European principles of inhibitor management in patients with haemophilia: implications of new treatment options. Orphanet Journal of Rare Diseases. London: England, 2020, vol. 15, No 1, p. 1-4. ISSN 1750-1172. Available from: https://dx.doi.org/10.1186/s13023-020-01511-8.
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Basic information
Original name European principles of inhibitor management in patients with haemophilia: implications of new treatment options
Authors HERMANS, C. (56 Belgium), P. L. F. GIANGRANDE (56 Belgium), B. O MAHONY (56 Belgium), P. DE KLEIJN (528 Netherlands), M. BEDFORD (826 United Kingdom of Great Britain and Northern Ireland), A. BATOROVA (703 Slovakia), Jan BLATNÝ (203 Czech Republic, belonging to the institution) and K. JANSONE (56 Belgium).
Edition Orphanet Journal of Rare Diseases, London, England, 2020, 1750-1172.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10603 Genetics and heredity
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.123
RIV identification code RIV/00216224:14110/20:00116531
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1186/s13023-020-01511-8
UT WoS 000567119900003
Keywords in English Haemophilia; Guidelines; Inhibitors; Factor VIII; Factor IX; Bypassing agents; Emicizumab; Immune tolerance
Tags 14110321, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 30/9/2020 11:02.
Abstract
In light of the rapidly changing landscape of haemophilia treatment, the authors of the position paper on the “European Principles of Inhibitor Management” published in 2018 (Table 1) now provide an update on the major impact of novel therapies that bypass and/or substitute clotting factor VIII (FVIII) and IX (FIX) in the care of haemophilia patients with FVIII- or FIXneutralizing allo-inhibitory antibodies (inhibitors).
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