Dental cell type atlas reveals stem and differentiated cell
types in mouse and human teeth

J 2020

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

KŘIVÁNEK, Jan, R. A. SOLDATOV, M. E. KASTRITI, T. CHONTOROTZEA, A. N. HERDINA et. al.

Basic information

Original name

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Authors

KŘIVÁNEK, Jan (203 Czech Republic, belonging to the institution), R. A. SOLDATOV, M. E. KASTRITI (203 Czech Republic), T. CHONTOROTZEA, A. N. HERDINA, J. PETERSEN, B. SZAROWSKA, Marie LANDOVA (203 Czech Republic), Veronika KOVÁŘ MATEJOVÁ (203 Czech Republic, belonging to the institution), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution), U. KUCHLER, I. V. ZDRILIC, A. VIJAYKUMAR, A. BALIC, P. MARANGONI, O. D. KLEIN, V. C. M. NEVES, V. YIANNI, P. T. SHARPE, T. HARKANY, B. D. METSCHER, M. BAJENOFF, M. MINA, K. FRIED, P. V. KHARCHENKO and I. ADAMEYKO (guarantor)

Edition

Nature Communications, London, Nature Publishing Group, 2020, 2041-1723

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 14.919

RIV identification code

RIV/00216224:14110/20:00116595

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41467-020-18512-7

UT WoS

000573746700005

Keywords in English

dental cell type; human teeth; mouse teeth

Abstract

V originále

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.

Links

LM2018129, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1428/2019, interní kód MU

Name: Onemocnění dutiny ústní – etiopatogeneze, diagnostika a léčba

Investor: Masaryk University, Category A

MUNI/H/1615/2018, interní kód MU

Name: Understanding of tooth developmental trajectories as a novel approach for dental regeneration

Investor: Masaryk University, Individual High risk/high gain projects

ROZV/23/LF17/2019, interní kód MU

Name: Vývoj a vnitřní uspořádání zubu

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

KŘIVÁNEK, Jan, R. A. SOLDATOV, M. E. KASTRITI, T. CHONTOROTZEA, A. N. HERDINA, J. PETERSEN, B. SZAROWSKA, Marie LANDOVA, Veronika KOVÁŘ MATEJOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, U. KUCHLER, I. V. ZDRILIC, A. VIJAYKUMAR, A. BALIC, P. MARANGONI, O. D. KLEIN, V. C. M. NEVES, V. YIANNI, P. T. SHARPE, T. HARKANY, B. D. METSCHER, M. BAJENOFF, M. MINA, K. FRIED, P. V. KHARCHENKO and I. ADAMEYKO. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nature Communications. London: Nature Publishing Group, 2020, vol. 11, No 1, p. 1-18. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-020-18512-7.

@article{1683658,
   author = {Křivánek, Jan and Soldatov, R. A. and Kastriti, M. E. and Chontorotzea, T. and Herdina, A. N. and Petersen, J. and Szarowska, B. and Landova, Marie and Kovář Matejová, Veronika and Izakovičová Hollá, Lydie and Kuchler, U. and Zdrilic, I. V. and Vijaykumar, A. and Balic, A. and Marangoni, P. and Klein, O. D. and Neves, V. C. M. and Yianni, V. and Sharpe, P. T. and Harkany, T. and Metscher, B. D. and Bajenoff, M. and Mina, M. and Fried, K. and Kharchenko, P. V. and Adameyko, I.},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41467-020-18512-7},
   keywords = {dental cell type; human teeth; mouse teeth},
   language = {eng},
   issn = {2041-1723},
   journal = {Nature Communications},
   title = {Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth},
   url = {https://www.nature.com/articles/s41467-020-18512-7.pdf},
   volume = {11},
   year = {2020}
}

TY  - JOUR
ID  - 1683658
AU  - Křivánek, Jan - Soldatov, R. A. - Kastriti, M. E. - Chontorotzea, T. - Herdina, A. N. - Petersen, J. - Szarowska, B. - Landova, Marie - Kovář Matejová, Veronika - Izakovičová Hollá, Lydie - Kuchler, U. - Zdrilic, I. V. - Vijaykumar, A. - Balic, A. - Marangoni, P. - Klein, O. D. - Neves, V. C. M. - Yianni, V. - Sharpe, P. T. - Harkany, T. - Metscher, B. D. - Bajenoff, M. - Mina, M. - Fried, K. - Kharchenko, P. V. - Adameyko, I.
PY  - 2020
TI  - Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
JF  - Nature Communications
VL  - 11
IS  - 1
SP  - 1-18
EP  - 1-18
PB  - Nature Publishing Group
SN  - 20411723
KW  - dental cell type
KW  - human teeth
KW  - mouse teeth
UR  - https://www.nature.com/articles/s41467-020-18512-7.pdf
L2  - https://www.nature.com/articles/s41467-020-18512-7.pdf
N2  - Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.
ER  -

KŘIVÁNEK, Jan, R. A. SOLDATOV, M. E. KASTRITI, T. CHONTOROTZEA, A. N. HERDINA, J. PETERSEN, B. SZAROWSKA, Marie LANDOVA, Veronika KOVÁŘ MATEJOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, U. KUCHLER, I. V. ZDRILIC, A. VIJAYKUMAR, A. BALIC, P. MARANGONI, O. D. KLEIN, V. C. M. NEVES, V. YIANNI, P. T. SHARPE, T. HARKANY, B. D. METSCHER, M. BAJENOFF, M. MINA, K. FRIED, P. V. KHARCHENKO and I. ADAMEYKO. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. \textit{Nature Communications}. London: Nature Publishing Group, 2020, vol.~11, No~1, p.~1-18. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/s41467-020-18512-7.

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