LABOUNEK, René, Jan VALOŠEK, Tomáš HORÁK, Alena SVÁTKOVÁ, Petr BEDNAŘÍK, Lubomír VOJTÍŠEK, Magda HORÁKOVÁ, Igor NESTRAŠIL, Christophe LENGLET, Julien COHEN-ADAD, Josef BEDNAŘÍK and Petr HLUŠTÍK. HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. Scientific Reports. London: Nature Publishing Group, vol. 10, No 1, p. 1-19. ISSN 2045-2322. doi:10.1038/s41598-020-70297-3. 2020.
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Basic information
Original name HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy
Authors LABOUNEK, René (203 Czech Republic), Jan VALOŠEK (203 Czech Republic), Tomáš HORÁK (203 Czech Republic, belonging to the institution), Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution), Petr BEDNAŘÍK (203 Czech Republic, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Magda HORÁKOVÁ (203 Czech Republic, belonging to the institution), Igor NESTRAŠIL (203 Czech Republic), Christophe LENGLET (250 France), Julien COHEN-ADAD (124 Canada), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Petr HLUŠTÍK (203 Czech Republic).
Edition Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.379
RIV identification code RIV/00216224:14110/20:00116731
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1038/s41598-020-70297-3
UT WoS 000585841900010
Keywords in English HARDI-ZOOMit protocol; presymptomatic myelopathy
Tags 14110221, CF MAFIL, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 5/1/2021 11:25.
Abstract
Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.
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LM2015062, research and development projectName: Národní infrastruktura pro biologické a medicínské zobrazování
Investor: Ministry of Education, Youth and Sports of the CR
LM2018129, research and development projectName: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging
Investor: Ministry of Education, Youth and Sports of the CR
LM2018140, research and development projectName: e-Infrastruktura CZ (Acronym: e-INFRA CZ)
Investor: Ministry of Education, Youth and Sports of the CR
NV18-04-00159, research and development projectName: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy
Investor: Ministry of Health of the CR
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