HARDI-ZOOMit protocol improves specificity to microstructural
changes in presymptomatic myelopathy

J 2020

HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy

LABOUNEK, René; Jan VALOŠEK; Tomáš HORÁK; Alena SVÁTKOVÁ; Petr BEDNAŘÍK et. al.

Basic information

Original name

HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy

Authors

LABOUNEK, René (203 Czech Republic); Jan VALOŠEK (203 Czech Republic); Tomáš HORÁK (203 Czech Republic, belonging to the institution); Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution); Petr BEDNAŘÍK (203 Czech Republic, belonging to the institution); Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution); Magda HORÁKOVÁ (203 Czech Republic, belonging to the institution); Igor NESTRAŠIL (203 Czech Republic); Christophe LENGLET (250 France); Julien COHEN-ADAD (124 Canada); Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Petr HLUŠTÍK (203 Czech Republic)

Edition

Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.380

RIV identification code

RIV/00216224:14110/20:00116731

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-020-70297-3

UT WoS

000585841900010

EID Scopus

2-s2.0-85080989889

Keywords in English

HARDI-ZOOMit protocol; presymptomatic myelopathy

Abstract

V originále

Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.

Links

LM2018140, research and development project

Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

NV18-04-00159, research and development project

Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministry of Health of the CR

90062, large research infrastructures

Name: Czech-BioImaging

90129, large research infrastructures

Name: Czech-BioImaging II

Cite

LABOUNEK, René; Jan VALOŠEK; Tomáš HORÁK; Alena SVÁTKOVÁ; Petr BEDNAŘÍK; Lubomír VOJTÍŠEK; Magda HORÁKOVÁ; Igor NESTRAŠIL; Christophe LENGLET; Julien COHEN-ADAD; Josef BEDNAŘÍK and Petr HLUŠTÍK. HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. Scientific Reports. London: Nature Publishing Group, 2020, vol. 10, No 1, p. 1-19. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-70297-3.

@article{1687183,
   author = {Labounek, René and Valošek, Jan and Horák, Tomáš and Svátková, Alena and Bednařík, Petr and Vojtíšek, Lubomír and Horáková, Magda and Nestrašil, Igor and Lenglet, Christophe and CohenandAdad, Julien and Bednařík, Josef and Hluštík, Petr},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-70297-3},
   keywords = {HARDI-ZOOMit protocol; presymptomatic myelopathy},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy},
   url = {https://www.nature.com/articles/s41598-020-70297-3},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1687183
AU  - Labounek, René - Valošek, Jan - Horák, Tomáš - Svátková, Alena - Bednařík, Petr - Vojtíšek, Lubomír - Horáková, Magda - Nestrašil, Igor - Lenglet, Christophe - Cohen-Adad, Julien - Bednařík, Josef - Hluštík, Petr
PY  - 2020
TI  - HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-19
EP  - 1-19
PB  - Nature Publishing Group
SN  - 20452322
KW  - HARDI-ZOOMit protocol
KW  - presymptomatic myelopathy
UR  - https://www.nature.com/articles/s41598-020-70297-3
L2  - https://www.nature.com/articles/s41598-020-70297-3
N2  - Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.
ER  -

LABOUNEK, René; Jan VALOŠEK; Tomáš HORÁK; Alena SVÁTKOVÁ; Petr BEDNAŘÍK; Lubomír VOJTÍŠEK; Magda HORÁKOVÁ; Igor NESTRAŠIL; Christophe LENGLET; Julien COHEN-ADAD; Josef BEDNAŘÍK and Petr HLUŠTÍK. HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, vol.~10, No~1, p.~1-19. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-70297-3.

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