Consideration of stiffness of wall layers is decisive for
patient-specific analysis of carotid artery with atheroma

J 2020

Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma

LISICKY, Ondrej, Aneta MALA, Zdeněk BEDNAŘÍK, Tomáš NOVOTNÝ, Jiri BURSA et. al.

Basic information

Original name

Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma

Authors

LISICKY, Ondrej (203 Czech Republic, guarantor), Aneta MALA (203 Czech Republic), Zdeněk BEDNAŘÍK (203 Czech Republic, belonging to the institution), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution) and Jiri BURSA (203 Czech Republic)

Edition

Plos one, San Francisco, Public Library of Science, 2020, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30109 Pathology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.240

RIV identification code

RIV/00216224:14110/20:00116735

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0239447

UT WoS

000576632300010

Keywords in English

carotid artery; atheroma; stiffness of wall layers

Abstract

V originále

The paper deals with the impact of chosen geometric and material factors on maximal stresses in carotid atherosclerotic plaque calculated using patient-specific finite element models. These stresses are believed to be decisive for the plaque vulnerability but all applied models suffer from inaccuracy of input data, especially when obtainedin vivoonly. One hundred computational models based onex vivoMRI are used to investigate the impact of wall thickness, MRI slice thickness, lipid core and fibrous tissue stiffness, and media anisotropy on the calculated peak plaque and peak cap stresses. The investigated factors are taken as continuous in the range based on published experimental results, only the impact of anisotropy is evaluated by comparison with a corresponding isotropic model. Design of Experiment concept is applied to assess the statistical significance of these investigated factors representing uncertainties in the input data of the model. The results show that consideration of realistic properties of arterial wall in the model is decisive for the stress evaluation; assignment of properties of fibrous tissue even to media and adventitia layers as done in some studies may induce up to eightfold overestimation of peak stress. The impact of MRI slice thickness may play a key role when local thin fibrous cap is present. Anisotropy of media layer is insignificant, and the stiffness of fibrous tissue and lipid core may become significant in some combinations.

Links

LM2015062, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

LISICKY, Ondrej, Aneta MALA, Zdeněk BEDNAŘÍK, Tomáš NOVOTNÝ and Jiri BURSA. Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma. Plos one. San Francisco: Public Library of Science, 2020, vol. 15, No 9, p. 1-18. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0239447.

@article{1687241,
   author = {Lisicky, Ondrej and Mala, Aneta and Bednařík, Zdeněk and Novotný, Tomáš and Bursa, Jiri},
   article_location = {San Francisco},
   article_number = {9},
   doi = {http://dx.doi.org/10.1371/journal.pone.0239447},
   keywords = {carotid artery; atheroma; stiffness of wall layers},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma},
   url = {https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239447&type=printable},
   volume = {15},
   year = {2020}
}

TY  - JOUR
ID  - 1687241
AU  - Lisicky, Ondrej - Mala, Aneta - Bednařík, Zdeněk - Novotný, Tomáš - Bursa, Jiri
PY  - 2020
TI  - Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma
JF  - Plos one
VL  - 15
IS  - 9
SP  - 1-18
EP  - 1-18
PB  - Public Library of Science
SN  - 19326203
KW  - carotid artery
KW  - atheroma
KW  - stiffness of wall layers
UR  - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239447&type=printable
L2  - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239447&type=printable
N2  - The paper deals with the impact of chosen geometric and material factors on maximal stresses in carotid atherosclerotic plaque calculated using patient-specific finite element models. These stresses are believed to be decisive for the plaque vulnerability but all applied models suffer from inaccuracy of input data, especially when obtainedin vivoonly. One hundred computational models based onex vivoMRI are used to investigate the impact of wall thickness, MRI slice thickness, lipid core and fibrous tissue stiffness, and media anisotropy on the calculated peak plaque and peak cap stresses. The investigated factors are taken as continuous in the range based on published experimental results, only the impact of anisotropy is evaluated by comparison with a corresponding isotropic model. Design of Experiment concept is applied to assess the statistical significance of these investigated factors representing uncertainties in the input data of the model. The results show that consideration of realistic properties of arterial wall in the model is decisive for the stress evaluation; assignment of properties of fibrous tissue even to media and adventitia layers as done in some studies may induce up to eightfold overestimation of peak stress. The impact of MRI slice thickness may play a key role when local thin fibrous cap is present. Anisotropy of media layer is insignificant, and the stiffness of fibrous tissue and lipid core may become significant in some combinations.
ER  -

LISICKY, Ondrej, Aneta MALA, Zdeněk BEDNAŘÍK, Tomáš NOVOTNÝ and Jiri BURSA. Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma. \textit{Plos one}. San Francisco: Public Library of Science, 2020, vol.~15, No~9, p.~1-18. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0239447.

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