The role of plant-derived natural substances as
immunomodulatory agents in carcinogenesis

J 2020

The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis

SAMEC, Marek, Alena LISKOVA, Lenka KOKLESOVA, Samson Mathews SAMUEL, Radovan MURIN et. al.

Basic information

Original name

The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis

Authors

SAMEC, Marek (703 Slovakia), Alena LISKOVA (703 Slovakia), Lenka KOKLESOVA (703 Slovakia), Samson Mathews SAMUEL (356 India), Radovan MURIN (703 Slovakia), Pavol ZUBOR (703 Slovakia), Jan BUJNAK (703 Slovakia), Taeg Kyu KWON (410 Republic of Korea), Dietrich BUSSELBERG (276 Germany), Robert PROSECKÝ (203 Czech Republic, belonging to the institution), Martin CAPRNDA (703 Slovakia), Luis RODRIGO (724 Spain), Rachele CICCOCIOPPO (380 Italy), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and Peter KUBATKA (703 Slovakia)

Edition

Journal of cancer research and clinical oncology, Germany, Springer-Verlag, 2020, 0171-5216

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.553

RIV identification code

RIV/00216224:14110/20:00116763

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00432-020-03424-2

UT WoS

000577893800001

Keywords in English

Cancer; Immunomodulation; Cytokines; Phytochemicals; Preclinical and clinical research

Abstract

V originále

The role of immune system in carcinogenesis represents fundamental events associated with cancer eradication; however, tumor evolution is connected with various mechanisms of tumor evasion and progression of cancer. Based on recent evidence, phytochemicals are directly associated with immunomodulation of the innate and adaptive immunity via different mechanisms of action including stimulation and amplification of immune cells, humoral compartments, and associated molecules. This comprehensive study focuses on immunomodulating potential of phytochemicals (mixture in plants or separately such as individual phytochemical) and their impact on regulation of immune response during cancer development, immune tolerance, and immune escape. Clinical application of phytochemicals as modulators of host immunity against cancer may represent perspective approach in anticancer therapy.

Citovat

SAMEC, Marek, Alena LISKOVA, Lenka KOKLESOVA, Samson Mathews SAMUEL, Radovan MURIN, Pavol ZUBOR, Jan BUJNAK, Taeg Kyu KWON, Dietrich BUSSELBERG, Robert PROSECKÝ, Martin CAPRNDA, Luis RODRIGO, Rachele CICCOCIOPPO, Peter KRUŽLIAK and Peter KUBATKA. The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis. Journal of cancer research and clinical oncology. Germany: Springer-Verlag, 2020, vol. 146, No 12, p. 3137-3154. ISSN 0171-5216. Available from: https://dx.doi.org/10.1007/s00432-020-03424-2.

@article{1687754,
   author = {Samec, Marek and Liskova, Alena and Koklesova, Lenka and Samuel, Samson Mathews and Murin, Radovan and Zubor, Pavol and Bujnak, Jan and Kwon, Taeg Kyu and Busselberg, Dietrich and Prosecký, Robert and Caprnda, Martin and Rodrigo, Luis and Ciccocioppo, Rachele and Kružliak, Peter and Kubatka, Peter},
   article_location = {Germany},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00432-020-03424-2},
   keywords = {Cancer; Immunomodulation; Cytokines; Phytochemicals; Preclinical and clinical research},
   language = {eng},
   issn = {0171-5216},
   journal = {Journal of cancer research and clinical oncology},
   title = {The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis},
   url = {https://link.springer.com/article/10.1007%2Fs00432-020-03424-2},
   volume = {146},
   year = {2020}
}

TY  - JOUR
ID  - 1687754
AU  - Samec, Marek - Liskova, Alena - Koklesova, Lenka - Samuel, Samson Mathews - Murin, Radovan - Zubor, Pavol - Bujnak, Jan - Kwon, Taeg Kyu - Busselberg, Dietrich - Prosecký, Robert - Caprnda, Martin - Rodrigo, Luis - Ciccocioppo, Rachele - Kružliak, Peter - Kubatka, Peter
PY  - 2020
TI  - The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis
JF  - Journal of cancer research and clinical oncology
VL  - 146
IS  - 12
SP  - 3137-3154
EP  - 3137-3154
PB  - Springer-Verlag
SN  - 01715216
KW  - Cancer
KW  - Immunomodulation
KW  - Cytokines
KW  - Phytochemicals
KW  - Preclinical and clinical research
UR  - https://link.springer.com/article/10.1007%2Fs00432-020-03424-2
L2  - https://link.springer.com/article/10.1007%2Fs00432-020-03424-2
N2  - The role of immune system in carcinogenesis represents fundamental events associated with cancer eradication; however, tumor evolution is connected with various mechanisms of tumor evasion and progression of cancer. Based on recent evidence, phytochemicals are directly associated with immunomodulation of the innate and adaptive immunity via different mechanisms of action including stimulation and amplification of immune cells, humoral compartments, and associated molecules. This comprehensive study focuses on immunomodulating potential of phytochemicals (mixture in plants or separately such as individual phytochemical) and their impact on regulation of immune response during cancer development, immune tolerance, and immune escape. Clinical application of phytochemicals as modulators of host immunity against cancer may represent perspective approach in anticancer therapy.
ER  -

SAMEC, Marek, Alena LISKOVA, Lenka KOKLESOVA, Samson Mathews SAMUEL, Radovan MURIN, Pavol ZUBOR, Jan BUJNAK, Taeg Kyu KWON, Dietrich BUSSELBERG, Robert PROSECKÝ, Martin CAPRNDA, Luis RODRIGO, Rachele CICCOCIOPPO, Peter KRUŽLIAK and Peter KUBATKA. The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2020, vol.~146, No~12, p.~3137-3154. ISSN~0171-5216. Available from: https://dx.doi.org/10.1007/s00432-020-03424-2.

Detailed Information on Publication Record