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@article{1688925,
author = {Čundrle, Ivan and Johnson, Bruce D. and Rea, Robert F. and Scott, Christopher G. and Somers, Virend K. and Olson, Lyle J.},
article_location = {PHILADELPHIA},
article_number = {10},
doi = {http://dx.doi.org/10.1016/j.cardfail.2020.03.006},
keywords = {Exercise oscillatory ventilation; heart failure; CO2 chemosensitivity; pacing},
language = {eng},
issn = {1071-9164},
journal = {JOURNAL OF CARDIAC FAILURE},
title = {Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy},
url = {https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub},
volume = {26},
year = {2020}
}
TY - JOUR
ID - 1688925
AU - Čundrle, Ivan - Johnson, Bruce D. - Rea, Robert F. - Scott, Christopher G. - Somers, Virend K. - Olson, Lyle J.
PY - 2020
TI - Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy
JF - JOURNAL OF CARDIAC FAILURE
VL - 26
IS - 10
SP - 832-840
EP - 832-840
PB - CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
SN - 10719164
KW - Exercise oscillatory ventilation
KW - heart failure
KW - CO2 chemosensitivity
KW - pacing
UR - https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub
N2 - Background: Exercise oscillatory ventilation (EOV) is a consequence of ventilatory control system instability and is commonly observed in patients with advanced heart failure (HF); it is associated with adverse prognosis. The goal of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) on oscillatory ventilation as quantified by a proposed EOV score. Methods and Results: Consecutive patients with HF (N = 35) who underwent clinically indicated CRT, cardiopulmonary exercise testing and carbon dioxide (CO2) chemosensitivity by rebreathe before and 4-6 months after CRT were included in this post hoc analysis. With CRT, EOV scores improved in 22 patients (63%). In these patients, left ventricular ejection fraction, left atrial volume, brain natriuretic peptide concentration, and CO2 chemosensitivity significantly improved after CRT (P < 0.05). Furthermore, minute ventilation per unit CO2 production significantly decreased, and end-tidal CO2 increased at rest and at peak exercise post-CRT. Multiple regression analysis showed only the change of CO2 chemosensitivity to be significantly associated with the improvement of the EOV score (b = 0.64; F = 11.3; P = 0.004). In the group without EOV score improvement (n = 13), though left ventricular ejection fraction significantly increased with CRT (P = 0.015), no significant changes in ventilation or gas exchange were observed. Conclusion: The EOV score was mitigated by CRT and was associated with decreased CO2 chemosensitivity.
ER -
ČUNDRLE, Ivan, Bruce D. JOHNSON, Robert F. REA, Christopher G. SCOTT, Virend K. SOMERS and Lyle J. OLSON. Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy. \textit{JOURNAL OF CARDIAC FAILURE}. PHILADELPHIA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, vol.~26, No~10, p.~832-840. ISSN~1071-9164. Available from: https://dx.doi.org/10.1016/j.cardfail.2020.03.006.
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