CHOVANCOVA, Barbora, Veronika LISKOVA, Petr BABULA and Olga KRIŽANOVÁ. Role of Sodium/Calcium Exchangers in Tumors. Biomolecules. BASEL: MDPI, 2020, vol. 10, No 9, p. 1-10. ISSN 2218-273X. Available from: https://dx.doi.org/10.3390/biom10091257.
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Basic information
Original name Role of Sodium/Calcium Exchangers in Tumors
Authors CHOVANCOVA, Barbora (703 Slovakia), Veronika LISKOVA (703 Slovakia), Petr BABULA (203 Czech Republic, belonging to the institution) and Olga KRIŽANOVÁ (703 Slovakia, guarantor, belonging to the institution).
Edition Biomolecules, BASEL, MDPI, 2020, 2218-273X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.879
RIV identification code RIV/00216224:14110/20:00116820
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3390/biom10091257
UT WoS 000579996000001
Keywords in English sodium-calcium exchanger; cancer cells; calcium; apoptosis
Tags 14110515, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 10/11/2021 08:30.
Abstract
The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted-calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells.
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